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FBXW7 in Cancer: What Has Been Unraveled Thus Far?

The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system (UPS) thus regulating cellular growth. FBXW7 is co...

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Autores principales: Sailo, Bethsebie Lalduhsaki, Banik, Kishore, Girisa, Sosmitha, Bordoloi, Devivasha, Fan, Lu, Halim, Clarissa Esmeralda, Wang, Hong, Kumar, Alan Prem, Zheng, Dali, Mao, Xinliang, Sethi, Gautam, Kunnumakkara, Ajaikumar Bahulayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406609/
https://www.ncbi.nlm.nih.gov/pubmed/30791487
http://dx.doi.org/10.3390/cancers11020246
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author Sailo, Bethsebie Lalduhsaki
Banik, Kishore
Girisa, Sosmitha
Bordoloi, Devivasha
Fan, Lu
Halim, Clarissa Esmeralda
Wang, Hong
Kumar, Alan Prem
Zheng, Dali
Mao, Xinliang
Sethi, Gautam
Kunnumakkara, Ajaikumar Bahulayan
author_facet Sailo, Bethsebie Lalduhsaki
Banik, Kishore
Girisa, Sosmitha
Bordoloi, Devivasha
Fan, Lu
Halim, Clarissa Esmeralda
Wang, Hong
Kumar, Alan Prem
Zheng, Dali
Mao, Xinliang
Sethi, Gautam
Kunnumakkara, Ajaikumar Bahulayan
author_sort Sailo, Bethsebie Lalduhsaki
collection PubMed
description The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system (UPS) thus regulating cellular growth. FBXW7 is considered as a potent tumor suppressor as most of its target substrates can function as potential growth promoters, including c-Myc, Notch, cyclin E, c-JUN, and KLF5. Its regulators include p53, C/EBP-δ, Numb, microRNAs, Pin 1, Hes-5, BMI1, Ebp2. Mounting evidence has indicated the involvement of aberrant expression of FBXW7 for tumorigenesis. Moreover, numerous studies have also shown its role in cancer cell chemosensitization, thereby demonstrating the importance of FBXW7 in the development of curative cancer therapy. This comprehensive review emphasizes on the targets, functions, regulators and expression of FBXW7 in different cancers and its involvement in sensitizing cancer cells to chemotherapeutic drugs.
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spelling pubmed-64066092019-03-21 FBXW7 in Cancer: What Has Been Unraveled Thus Far? Sailo, Bethsebie Lalduhsaki Banik, Kishore Girisa, Sosmitha Bordoloi, Devivasha Fan, Lu Halim, Clarissa Esmeralda Wang, Hong Kumar, Alan Prem Zheng, Dali Mao, Xinliang Sethi, Gautam Kunnumakkara, Ajaikumar Bahulayan Cancers (Basel) Review The FBXW7 (F-box with 7 tandem WD40) protein encoded by the gene FBXW7 is one of the crucial components of ubiquitin ligase called Skp1-Cullin1-F-box (SCF) complex that aids in the degradation of many oncoproteins via the ubiquitin-proteasome system (UPS) thus regulating cellular growth. FBXW7 is considered as a potent tumor suppressor as most of its target substrates can function as potential growth promoters, including c-Myc, Notch, cyclin E, c-JUN, and KLF5. Its regulators include p53, C/EBP-δ, Numb, microRNAs, Pin 1, Hes-5, BMI1, Ebp2. Mounting evidence has indicated the involvement of aberrant expression of FBXW7 for tumorigenesis. Moreover, numerous studies have also shown its role in cancer cell chemosensitization, thereby demonstrating the importance of FBXW7 in the development of curative cancer therapy. This comprehensive review emphasizes on the targets, functions, regulators and expression of FBXW7 in different cancers and its involvement in sensitizing cancer cells to chemotherapeutic drugs. MDPI 2019-02-19 /pmc/articles/PMC6406609/ /pubmed/30791487 http://dx.doi.org/10.3390/cancers11020246 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Sailo, Bethsebie Lalduhsaki
Banik, Kishore
Girisa, Sosmitha
Bordoloi, Devivasha
Fan, Lu
Halim, Clarissa Esmeralda
Wang, Hong
Kumar, Alan Prem
Zheng, Dali
Mao, Xinliang
Sethi, Gautam
Kunnumakkara, Ajaikumar Bahulayan
FBXW7 in Cancer: What Has Been Unraveled Thus Far?
title FBXW7 in Cancer: What Has Been Unraveled Thus Far?
title_full FBXW7 in Cancer: What Has Been Unraveled Thus Far?
title_fullStr FBXW7 in Cancer: What Has Been Unraveled Thus Far?
title_full_unstemmed FBXW7 in Cancer: What Has Been Unraveled Thus Far?
title_short FBXW7 in Cancer: What Has Been Unraveled Thus Far?
title_sort fbxw7 in cancer: what has been unraveled thus far?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406609/
https://www.ncbi.nlm.nih.gov/pubmed/30791487
http://dx.doi.org/10.3390/cancers11020246
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