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Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver
Functional food ingredients, including prebiotics, have been increasingly developed for human health. The improvement of the human intestinal environment is one of their main targets. Fructooligosaccarides (FOS) are oligosaccharide fructans that are well studied and commercialized prebiotics. 1-Kest...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406667/ https://www.ncbi.nlm.nih.gov/pubmed/30781821 http://dx.doi.org/10.3390/foods8020069 |
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author | Tochio, Takumi Ueno, Yuki Kitaura, Yasuyuki Shinohara, Mikako Kadota, Yoshihiro Minoda, Kanako Shimomura, Yoshiharu Osawa, Toshihiko |
author_facet | Tochio, Takumi Ueno, Yuki Kitaura, Yasuyuki Shinohara, Mikako Kadota, Yoshihiro Minoda, Kanako Shimomura, Yoshiharu Osawa, Toshihiko |
author_sort | Tochio, Takumi |
collection | PubMed |
description | Functional food ingredients, including prebiotics, have been increasingly developed for human health. The improvement of the human intestinal environment is one of their main targets. Fructooligosaccarides (FOS) are oligosaccharide fructans that are well studied and commercialized prebiotics. 1-Kestose, one of the components of FOS, is considered to be a key prebiotic component in FOS. However, to our knowledge, no studies have been reported on the physiological efficacy of 1-Kestose regarding its anti-oxidative activity. In the present study, we examined the effects of dietary 1-Kestose on gene expression of antioxidative enzymes in the liver, kidney and epididymal adipose tissue of mice by quantitative RT-PCR (qRT-PCR). We demonstrated that a 1-Kestose-rich diet increased mRNA and enzymatic activity levels of glutathione-S-transferase (GST) in mouse liver. These results suggest the possibility that dietary 1-Kestose as a prebiotic may enhance antioxidative activity in mice. |
format | Online Article Text |
id | pubmed-6406667 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64066672019-03-19 Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver Tochio, Takumi Ueno, Yuki Kitaura, Yasuyuki Shinohara, Mikako Kadota, Yoshihiro Minoda, Kanako Shimomura, Yoshiharu Osawa, Toshihiko Foods Article Functional food ingredients, including prebiotics, have been increasingly developed for human health. The improvement of the human intestinal environment is one of their main targets. Fructooligosaccarides (FOS) are oligosaccharide fructans that are well studied and commercialized prebiotics. 1-Kestose, one of the components of FOS, is considered to be a key prebiotic component in FOS. However, to our knowledge, no studies have been reported on the physiological efficacy of 1-Kestose regarding its anti-oxidative activity. In the present study, we examined the effects of dietary 1-Kestose on gene expression of antioxidative enzymes in the liver, kidney and epididymal adipose tissue of mice by quantitative RT-PCR (qRT-PCR). We demonstrated that a 1-Kestose-rich diet increased mRNA and enzymatic activity levels of glutathione-S-transferase (GST) in mouse liver. These results suggest the possibility that dietary 1-Kestose as a prebiotic may enhance antioxidative activity in mice. MDPI 2019-02-13 /pmc/articles/PMC6406667/ /pubmed/30781821 http://dx.doi.org/10.3390/foods8020069 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Tochio, Takumi Ueno, Yuki Kitaura, Yasuyuki Shinohara, Mikako Kadota, Yoshihiro Minoda, Kanako Shimomura, Yoshiharu Osawa, Toshihiko Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver |
title | Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver |
title_full | Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver |
title_fullStr | Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver |
title_full_unstemmed | Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver |
title_short | Feeding of 1-Kestose Induces Glutathione-S-Transferase Expression in Mouse Liver |
title_sort | feeding of 1-kestose induces glutathione-s-transferase expression in mouse liver |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406667/ https://www.ncbi.nlm.nih.gov/pubmed/30781821 http://dx.doi.org/10.3390/foods8020069 |
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