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The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day

A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, t...

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Autores principales: Zhu, Hongyan, Li, Rui, Zhou, Su, Zhang, Suhui, Wang, Yu, Liu, Shihong, Song, Qingwen, Chang, Xiuli, Zhang, Yubin, Liu, Luqing, Tang, Liming, Zhou, Zhijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406674/
https://www.ncbi.nlm.nih.gov/pubmed/30769872
http://dx.doi.org/10.3390/ijerph16040553
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author Zhu, Hongyan
Li, Rui
Zhou, Su
Zhang, Suhui
Wang, Yu
Liu, Shihong
Song, Qingwen
Chang, Xiuli
Zhang, Yubin
Liu, Luqing
Tang, Liming
Zhou, Zhijun
author_facet Zhu, Hongyan
Li, Rui
Zhou, Su
Zhang, Suhui
Wang, Yu
Liu, Shihong
Song, Qingwen
Chang, Xiuli
Zhang, Yubin
Liu, Luqing
Tang, Liming
Zhou, Zhijun
author_sort Zhu, Hongyan
collection PubMed
description A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Therefore, more attention should be paid to this herbicide.
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spelling pubmed-64066742019-03-21 The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day Zhu, Hongyan Li, Rui Zhou, Su Zhang, Suhui Wang, Yu Liu, Shihong Song, Qingwen Chang, Xiuli Zhang, Yubin Liu, Luqing Tang, Liming Zhou, Zhijun Int J Environ Res Public Health Article A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Therefore, more attention should be paid to this herbicide. MDPI 2019-02-14 2019-02 /pmc/articles/PMC6406674/ /pubmed/30769872 http://dx.doi.org/10.3390/ijerph16040553 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhu, Hongyan
Li, Rui
Zhou, Su
Zhang, Suhui
Wang, Yu
Liu, Shihong
Song, Qingwen
Chang, Xiuli
Zhang, Yubin
Liu, Luqing
Tang, Liming
Zhou, Zhijun
The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day
title The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day
title_full The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day
title_fullStr The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day
title_full_unstemmed The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day
title_short The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day
title_sort oral noael of flurochloridone in male wistar rats in ninety-day subchronic toxicity test was 3mg/kg/day
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406674/
https://www.ncbi.nlm.nih.gov/pubmed/30769872
http://dx.doi.org/10.3390/ijerph16040553
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