Cargando…
The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day
A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, t...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406674/ https://www.ncbi.nlm.nih.gov/pubmed/30769872 http://dx.doi.org/10.3390/ijerph16040553 |
_version_ | 1783401372288286720 |
---|---|
author | Zhu, Hongyan Li, Rui Zhou, Su Zhang, Suhui Wang, Yu Liu, Shihong Song, Qingwen Chang, Xiuli Zhang, Yubin Liu, Luqing Tang, Liming Zhou, Zhijun |
author_facet | Zhu, Hongyan Li, Rui Zhou, Su Zhang, Suhui Wang, Yu Liu, Shihong Song, Qingwen Chang, Xiuli Zhang, Yubin Liu, Luqing Tang, Liming Zhou, Zhijun |
author_sort | Zhu, Hongyan |
collection | PubMed |
description | A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Therefore, more attention should be paid to this herbicide. |
format | Online Article Text |
id | pubmed-6406674 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64066742019-03-21 The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day Zhu, Hongyan Li, Rui Zhou, Su Zhang, Suhui Wang, Yu Liu, Shihong Song, Qingwen Chang, Xiuli Zhang, Yubin Liu, Luqing Tang, Liming Zhou, Zhijun Int J Environ Res Public Health Article A ninety-day toxicity and toxicokinetics of flurochloridone (FLC) were studied in male Wistar rats with oral administration at doses of 3 mg/kg and 10 mg/kg respectively, following the previous study. Apparent toxicity to reproductive system of male rats was still observed at the dose of 10 mg/kg, trace amounts of FLC were still detected 24 hours after administration, testicular weight, epididymal weight and serum testosterone were significantly reduced and sperm abnormalities in epididymis were significantly increased. No abnormalities were found in 3 mg/kg group, it indicated that no-observed-adverse-effect level (NOAEL) of FLC in male rats was 3 mg/kg/day, far below the dose of 20 mg/kg/day reported by European Food Safety Authority (EFSA). Therefore, more attention should be paid to this herbicide. MDPI 2019-02-14 2019-02 /pmc/articles/PMC6406674/ /pubmed/30769872 http://dx.doi.org/10.3390/ijerph16040553 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhu, Hongyan Li, Rui Zhou, Su Zhang, Suhui Wang, Yu Liu, Shihong Song, Qingwen Chang, Xiuli Zhang, Yubin Liu, Luqing Tang, Liming Zhou, Zhijun The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
title | The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
title_full | The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
title_fullStr | The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
title_full_unstemmed | The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
title_short | The Oral NOAEL of Flurochloridone in Male Wistar Rats in Ninety-Day Subchronic Toxicity Test Was 3mg/kg/day |
title_sort | oral noael of flurochloridone in male wistar rats in ninety-day subchronic toxicity test was 3mg/kg/day |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406674/ https://www.ncbi.nlm.nih.gov/pubmed/30769872 http://dx.doi.org/10.3390/ijerph16040553 |
work_keys_str_mv | AT zhuhongyan theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT lirui theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT zhousu theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT zhangsuhui theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT wangyu theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT liushihong theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT songqingwen theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT changxiuli theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT zhangyubin theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT liuluqing theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT tangliming theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT zhouzhijun theoralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT zhuhongyan oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT lirui oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT zhousu oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT zhangsuhui oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT wangyu oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT liushihong oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT songqingwen oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT changxiuli oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT zhangyubin oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT liuluqing oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT tangliming oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday AT zhouzhijun oralnoaelofflurochloridoneinmalewistarratsinninetydaysubchronictoxicitytestwas3mgkgday |