MEK Inhibition Induces Canonical WNT Signaling through YAP in KRAS Mutated HCT-15 Cells, and a Cancer Preventive FOXO3/FOXM1 Ratio in Combination with TNKS Inhibition

The majority of colorectal cancers are induced by subsequent mutations in APC and KRAS genes leading to aberrant activation of both canonical WNT and RAS signaling. However, due to induction of feedback rescue mechanisms some cancers do not respond well to targeted inhibitor treatments. In this stud...

Descripción completa

Detalles Bibliográficos
Autores principales: Solberg, Nina Therese, Melheim, Maria, Strand, Martin Frank, Olsen, Petter Angell, Krauss, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406699/
https://www.ncbi.nlm.nih.gov/pubmed/30717152
http://dx.doi.org/10.3390/cancers11020164

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406699/
https://www.ncbi.nlm.nih.gov/pubmed/30717152
http://dx.doi.org/10.3390/cancers11020164

Ejemplares similares