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The MEK-ERK-MST1 Axis Potentiates the Activation of the Extrinsic Apoptotic Pathway during GDC-0941 Treatment in Jurkat T Cells

The discrete activation of individual caspases is essential during T-cell development, activation, and apoptosis. Humans carrying nonfunctional caspase-8 and caspase-8 conditional knockout mice exhibit several defects in the progression of naive CD4(+) T cells to the effector stage. MST1, a key kina...

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Detalles Bibliográficos
Autores principales:	Nováková, Jana, Talacko, Pavel, Novák, Petr, Vališ, Karel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406719/ https://www.ncbi.nlm.nih.gov/pubmed/30795621 http://dx.doi.org/10.3390/cells8020191

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