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Oxaliplatin-Based Intra-Arterial Chemotherapy in Colo-Rectal Cancer Liver Metastases: A Review from Pharmacology to Clinical Application
Liver metastases (LM) are often consequences of colo-rectal cancer (CRC)and the majority of patients have unresectable LM. Oxaliplatin-based intravenous chemotherapy represents the gold standard treatment for CRC. Intravenous oxaliplatin has several side effects i.e., nephrologic, hematologic and ne...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406804/ https://www.ncbi.nlm.nih.gov/pubmed/30682873 http://dx.doi.org/10.3390/cancers11020141 |
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author | Ranieri, Girolamo Laforgia, Mariarita Nardulli, Patrizia Ferraiuolo, Simona Molinari, Pasquale Marech, Ilaria Gadaleta, Cosmo Damiano |
author_facet | Ranieri, Girolamo Laforgia, Mariarita Nardulli, Patrizia Ferraiuolo, Simona Molinari, Pasquale Marech, Ilaria Gadaleta, Cosmo Damiano |
author_sort | Ranieri, Girolamo |
collection | PubMed |
description | Liver metastases (LM) are often consequences of colo-rectal cancer (CRC)and the majority of patients have unresectable LM. Oxaliplatin-based intravenous chemotherapy represents the gold standard treatment for CRC. Intravenous oxaliplatin has several side effects i.e., nephrologic, hematologic and neurological toxicity. Moreover, hepatic arterial infusion (HAI) of antitumor drugs deeply modifies the treatment of LMCRC due to the knowledge that LM are perfused by the hepatic artery network, whereas healthy tissue is perfused by the portal vein. Therefore, oxaliplatin-based HAI becomes an interesting possibility to treat LMCRC. The aim of this review is to shed light on the important impact of the oxaliplatin-based chemotherapy from a non-conventional clinical point of view, considering that, being universally accepted its antitumor effect if administered intravenously, fragmentary information are known about its clinical applications and benefits deriving from intra-arterial administration in loco-regional chemotherapy. |
format | Online Article Text |
id | pubmed-6406804 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64068042019-03-21 Oxaliplatin-Based Intra-Arterial Chemotherapy in Colo-Rectal Cancer Liver Metastases: A Review from Pharmacology to Clinical Application Ranieri, Girolamo Laforgia, Mariarita Nardulli, Patrizia Ferraiuolo, Simona Molinari, Pasquale Marech, Ilaria Gadaleta, Cosmo Damiano Cancers (Basel) Review Liver metastases (LM) are often consequences of colo-rectal cancer (CRC)and the majority of patients have unresectable LM. Oxaliplatin-based intravenous chemotherapy represents the gold standard treatment for CRC. Intravenous oxaliplatin has several side effects i.e., nephrologic, hematologic and neurological toxicity. Moreover, hepatic arterial infusion (HAI) of antitumor drugs deeply modifies the treatment of LMCRC due to the knowledge that LM are perfused by the hepatic artery network, whereas healthy tissue is perfused by the portal vein. Therefore, oxaliplatin-based HAI becomes an interesting possibility to treat LMCRC. The aim of this review is to shed light on the important impact of the oxaliplatin-based chemotherapy from a non-conventional clinical point of view, considering that, being universally accepted its antitumor effect if administered intravenously, fragmentary information are known about its clinical applications and benefits deriving from intra-arterial administration in loco-regional chemotherapy. MDPI 2019-01-24 /pmc/articles/PMC6406804/ /pubmed/30682873 http://dx.doi.org/10.3390/cancers11020141 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Ranieri, Girolamo Laforgia, Mariarita Nardulli, Patrizia Ferraiuolo, Simona Molinari, Pasquale Marech, Ilaria Gadaleta, Cosmo Damiano Oxaliplatin-Based Intra-Arterial Chemotherapy in Colo-Rectal Cancer Liver Metastases: A Review from Pharmacology to Clinical Application |
title | Oxaliplatin-Based Intra-Arterial Chemotherapy in Colo-Rectal Cancer Liver Metastases: A Review from Pharmacology to Clinical Application |
title_full | Oxaliplatin-Based Intra-Arterial Chemotherapy in Colo-Rectal Cancer Liver Metastases: A Review from Pharmacology to Clinical Application |
title_fullStr | Oxaliplatin-Based Intra-Arterial Chemotherapy in Colo-Rectal Cancer Liver Metastases: A Review from Pharmacology to Clinical Application |
title_full_unstemmed | Oxaliplatin-Based Intra-Arterial Chemotherapy in Colo-Rectal Cancer Liver Metastases: A Review from Pharmacology to Clinical Application |
title_short | Oxaliplatin-Based Intra-Arterial Chemotherapy in Colo-Rectal Cancer Liver Metastases: A Review from Pharmacology to Clinical Application |
title_sort | oxaliplatin-based intra-arterial chemotherapy in colo-rectal cancer liver metastases: a review from pharmacology to clinical application |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406804/ https://www.ncbi.nlm.nih.gov/pubmed/30682873 http://dx.doi.org/10.3390/cancers11020141 |
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