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Rodents Versus Pig Model for Assessing the Performance of Serotype Chimeric Ad5/3 Oncolytic Adenoviruses

Oncolytic adenoviruses (Ad) are promising tools for cancer therapeutics. Most Ad-based therapies utilize species C serotypes, with Adenovirus type 5 (Ad5) most commonly employed. Prior clinical trials demonstrated low efficiency of oncolytic Ad5 vectors, mainly due to the absence of Ad5 primary rece...

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Detalles Bibliográficos
Autores principales:	Koodie, Lisa, Robertson, Matthew G., Chandrashekar, Malavika, Ruth, George, Dunning, Michele, Bianco, Richard W., Davydova, Julia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406826/ https://www.ncbi.nlm.nih.gov/pubmed/30744019 http://dx.doi.org/10.3390/cancers11020198

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