Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029

Tetraspanins are exposed at the surface of cellular membranes, which allows for the fixation of cognate antibodies. Developing specific antibodies in conjunction with genetic data would largely contribute to deciphering their biological behavior. In this short review, we summarize the main functions...

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Detalles Bibliográficos
Autores principales: Bonnet, Mathilde, Maisonial-Besset, Aurélie, Zhu, Yingying, Witkowski, Tiffany, Roche, Gwenaëlle, Boucheix, Claude, Greco, Céline, Degoul, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406856/
https://www.ncbi.nlm.nih.gov/pubmed/30769765
http://dx.doi.org/10.3390/cancers11020179
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author Bonnet, Mathilde
Maisonial-Besset, Aurélie
Zhu, Yingying
Witkowski, Tiffany
Roche, Gwenaëlle
Boucheix, Claude
Greco, Céline
Degoul, Françoise
author_facet Bonnet, Mathilde
Maisonial-Besset, Aurélie
Zhu, Yingying
Witkowski, Tiffany
Roche, Gwenaëlle
Boucheix, Claude
Greco, Céline
Degoul, Françoise
author_sort Bonnet, Mathilde
collection PubMed
description Tetraspanins are exposed at the surface of cellular membranes, which allows for the fixation of cognate antibodies. Developing specific antibodies in conjunction with genetic data would largely contribute to deciphering their biological behavior. In this short review, we summarize the main functions of Tspan8/Co-029 and its role in the biology of tumor cells. Based on data collected from recently reported studies, the possibilities of using antibodies to target Tspan8 in immunotherapy or radioimmunotherapy approaches are also discussed.
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spelling pubmed-64068562019-03-21 Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029 Bonnet, Mathilde Maisonial-Besset, Aurélie Zhu, Yingying Witkowski, Tiffany Roche, Gwenaëlle Boucheix, Claude Greco, Céline Degoul, Françoise Cancers (Basel) Review Tetraspanins are exposed at the surface of cellular membranes, which allows for the fixation of cognate antibodies. Developing specific antibodies in conjunction with genetic data would largely contribute to deciphering their biological behavior. In this short review, we summarize the main functions of Tspan8/Co-029 and its role in the biology of tumor cells. Based on data collected from recently reported studies, the possibilities of using antibodies to target Tspan8 in immunotherapy or radioimmunotherapy approaches are also discussed. MDPI 2019-02-03 /pmc/articles/PMC6406856/ /pubmed/30769765 http://dx.doi.org/10.3390/cancers11020179 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bonnet, Mathilde
Maisonial-Besset, Aurélie
Zhu, Yingying
Witkowski, Tiffany
Roche, Gwenaëlle
Boucheix, Claude
Greco, Céline
Degoul, Françoise
Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029
title Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029
title_full Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029
title_fullStr Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029
title_full_unstemmed Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029
title_short Targeting the Tetraspanins with Monoclonal Antibodies in Oncology: Focus on Tspan8/Co-029
title_sort targeting the tetraspanins with monoclonal antibodies in oncology: focus on tspan8/co-029
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406856/
https://www.ncbi.nlm.nih.gov/pubmed/30769765
http://dx.doi.org/10.3390/cancers11020179
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