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White Matter Changes in Patients with Alzheimer’s Disease and Associated Factors

Alzheimer’s disease (AD) is traditionally thought of as a neurodegenerative disease. Recent evidence shows that beta amyloid-independent vascular changes and beta amyloid-dependent neuronal dysfunction both equally influence the disease, leading to loss of structural and functional connectivity. Whi...

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Autores principales: Kao, Yi-Hui, Chou, Mei-Chuan, Chen, Chun-Hung, Yang, Yuan-Han
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406891/
https://www.ncbi.nlm.nih.gov/pubmed/30717182
http://dx.doi.org/10.3390/jcm8020167
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author Kao, Yi-Hui
Chou, Mei-Chuan
Chen, Chun-Hung
Yang, Yuan-Han
author_facet Kao, Yi-Hui
Chou, Mei-Chuan
Chen, Chun-Hung
Yang, Yuan-Han
author_sort Kao, Yi-Hui
collection PubMed
description Alzheimer’s disease (AD) is traditionally thought of as a neurodegenerative disease. Recent evidence shows that beta amyloid-independent vascular changes and beta amyloid-dependent neuronal dysfunction both equally influence the disease, leading to loss of structural and functional connectivity. White matter changes (WMCs) in the brain are commonly observed in dementia patients. The effect of vascular factors on WMCs and the relationship between WMCs and severity of AD in patients remain to be clarified. We recruited 501 clinically diagnosed probable AD patients with a series of comprehensive neuropsychological tests and brain imaging. The WMCs in cerebral CT or MRI were rated using both the modified Fazekas scale and the combined CT-MRI age related WMC (ARWMC) rating scale. Periventricular WMCs were observed in 79.4% of the patients and deep WMCs were also seen in 48.7% of the patients. WMC scores were significantly higher in the advanced dementia stage in periventricular WMCs (p = 0.001) and total ARWMCs (p < 0.001). Age and disease severity were both independently associated with WMCs score, particularly in the total, frontal and parieto-occipital areas. Vascular factors including hypertension, diabetes mellitus, and gender were not significantly associated with WMCs. In conclusion, both age and severity of dementia were significantly associated with WMCs in AD patients. These associations highlight future research targets.
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spelling pubmed-64068912019-03-22 White Matter Changes in Patients with Alzheimer’s Disease and Associated Factors Kao, Yi-Hui Chou, Mei-Chuan Chen, Chun-Hung Yang, Yuan-Han J Clin Med Article Alzheimer’s disease (AD) is traditionally thought of as a neurodegenerative disease. Recent evidence shows that beta amyloid-independent vascular changes and beta amyloid-dependent neuronal dysfunction both equally influence the disease, leading to loss of structural and functional connectivity. White matter changes (WMCs) in the brain are commonly observed in dementia patients. The effect of vascular factors on WMCs and the relationship between WMCs and severity of AD in patients remain to be clarified. We recruited 501 clinically diagnosed probable AD patients with a series of comprehensive neuropsychological tests and brain imaging. The WMCs in cerebral CT or MRI were rated using both the modified Fazekas scale and the combined CT-MRI age related WMC (ARWMC) rating scale. Periventricular WMCs were observed in 79.4% of the patients and deep WMCs were also seen in 48.7% of the patients. WMC scores were significantly higher in the advanced dementia stage in periventricular WMCs (p = 0.001) and total ARWMCs (p < 0.001). Age and disease severity were both independently associated with WMCs score, particularly in the total, frontal and parieto-occipital areas. Vascular factors including hypertension, diabetes mellitus, and gender were not significantly associated with WMCs. In conclusion, both age and severity of dementia were significantly associated with WMCs in AD patients. These associations highlight future research targets. MDPI 2019-02-01 /pmc/articles/PMC6406891/ /pubmed/30717182 http://dx.doi.org/10.3390/jcm8020167 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kao, Yi-Hui
Chou, Mei-Chuan
Chen, Chun-Hung
Yang, Yuan-Han
White Matter Changes in Patients with Alzheimer’s Disease and Associated Factors
title White Matter Changes in Patients with Alzheimer’s Disease and Associated Factors
title_full White Matter Changes in Patients with Alzheimer’s Disease and Associated Factors
title_fullStr White Matter Changes in Patients with Alzheimer’s Disease and Associated Factors
title_full_unstemmed White Matter Changes in Patients with Alzheimer’s Disease and Associated Factors
title_short White Matter Changes in Patients with Alzheimer’s Disease and Associated Factors
title_sort white matter changes in patients with alzheimer’s disease and associated factors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406891/
https://www.ncbi.nlm.nih.gov/pubmed/30717182
http://dx.doi.org/10.3390/jcm8020167
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