Cargando…
Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration
Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of sarcopenia, prolonged hospitalization, and lo...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406986/ https://www.ncbi.nlm.nih.gov/pubmed/30791569 http://dx.doi.org/10.3390/cells8020183 |
_version_ | 1783401452022005760 |
---|---|
author | Lee, David E. Bareja, Akshay Bartlett, David B. White, James P. |
author_facet | Lee, David E. Bareja, Akshay Bartlett, David B. White, James P. |
author_sort | Lee, David E. |
collection | PubMed |
description | Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of sarcopenia, prolonged hospitalization, and loss of autonomy. Although several age-sensitive pathways have been identified, further investigation is needed to define targets of cellular dysfunction. Autophagy, a process of cellular catabolism, is emerging as a key regulator of muscle regeneration affecting stem cell, immune cell, and myofiber function. Muscle stem cell senescence is associated with a suppression of autophagy during key phases of the regenerative program. Macrophages, a key immune cell involved in muscle repair, also rely on autophagy to aid in tissue repair. This review will focus on the role of autophagy in various aspects of the regenerative program, including adult skeletal muscle stem cells, monocytes/macrophages, and corresponding age-associated dysfunction. Furthermore, we will highlight rejuvenation strategies that alter autophagy to improve muscle regenerative function. |
format | Online Article Text |
id | pubmed-6406986 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64069862019-03-19 Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration Lee, David E. Bareja, Akshay Bartlett, David B. White, James P. Cells Review Skeletal muscle has remarkable regenerative capacity, relying on precise coordination between resident muscle stem cells (satellite cells) and the immune system. The age-related decline in skeletal muscle regenerative capacity contributes to the onset of sarcopenia, prolonged hospitalization, and loss of autonomy. Although several age-sensitive pathways have been identified, further investigation is needed to define targets of cellular dysfunction. Autophagy, a process of cellular catabolism, is emerging as a key regulator of muscle regeneration affecting stem cell, immune cell, and myofiber function. Muscle stem cell senescence is associated with a suppression of autophagy during key phases of the regenerative program. Macrophages, a key immune cell involved in muscle repair, also rely on autophagy to aid in tissue repair. This review will focus on the role of autophagy in various aspects of the regenerative program, including adult skeletal muscle stem cells, monocytes/macrophages, and corresponding age-associated dysfunction. Furthermore, we will highlight rejuvenation strategies that alter autophagy to improve muscle regenerative function. MDPI 2019-02-20 /pmc/articles/PMC6406986/ /pubmed/30791569 http://dx.doi.org/10.3390/cells8020183 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lee, David E. Bareja, Akshay Bartlett, David B. White, James P. Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title | Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title_full | Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title_fullStr | Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title_full_unstemmed | Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title_short | Autophagy as a Therapeutic Target to Enhance Aged Muscle Regeneration |
title_sort | autophagy as a therapeutic target to enhance aged muscle regeneration |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6406986/ https://www.ncbi.nlm.nih.gov/pubmed/30791569 http://dx.doi.org/10.3390/cells8020183 |
work_keys_str_mv | AT leedavide autophagyasatherapeutictargettoenhanceagedmuscleregeneration AT barejaakshay autophagyasatherapeutictargettoenhanceagedmuscleregeneration AT bartlettdavidb autophagyasatherapeutictargettoenhanceagedmuscleregeneration AT whitejamesp autophagyasatherapeutictargettoenhanceagedmuscleregeneration |