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The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock
Sepsis is a life-threatening organ dysfunction caused by a dysregulated host-response to infections. Osteopontin (OPN) is an extracellular matrix protein involved in the inflammatory response. Our aim was to evaluate the diagnostic and prognostic performance in sepsis of a single OPN determination i...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407102/ https://www.ncbi.nlm.nih.gov/pubmed/30781721 http://dx.doi.org/10.3390/cells8020174 |
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author | Castello, Luigi Mario Baldrighi, Marco Molinari, Luca Salmi, Livia Cantaluppi, Vincenzo Vaschetto, Rosanna Zunino, Greta Quaglia, Marco Bellan, Mattia Gavelli, Francesco Navalesi, Paolo Avanzi, Gian Carlo Chiocchetti, Annalisa |
author_facet | Castello, Luigi Mario Baldrighi, Marco Molinari, Luca Salmi, Livia Cantaluppi, Vincenzo Vaschetto, Rosanna Zunino, Greta Quaglia, Marco Bellan, Mattia Gavelli, Francesco Navalesi, Paolo Avanzi, Gian Carlo Chiocchetti, Annalisa |
author_sort | Castello, Luigi Mario |
collection | PubMed |
description | Sepsis is a life-threatening organ dysfunction caused by a dysregulated host-response to infections. Osteopontin (OPN) is an extracellular matrix protein involved in the inflammatory response. Our aim was to evaluate the diagnostic and prognostic performance in sepsis of a single OPN determination in the Emergency Department (ED). We conducted a single-centre prospective observational study in an Italian ED where we enrolled 102 consecutive patients presenting with suspected infection and qSOFA ≥ 2. OPN plasma concentration was found to be an independent predictor of sepsis (OR = 1.020, 95% CI 1.002–1.039, p = 0.031) and the diagnostic receiver operating characteristic (ROC) curve resulted in an area under the curve (AUC) of 0.878. OPN levels were positively correlated to plasma creatinine (r = 0.401 with p = 0.0001), but this relation was not explained by the development of acute kidney injury (AKI), since no difference was found in OPN concentration between AKI and non-AKI patients. The analysis of 30-days mortality showed no significant difference in OPN levels between alive and dead patients (p = 0.482). In conclusion, a single determination of OPN concentration helped to identify patients with sepsis in the ED, but it was not able to predict poor prognosis in our cohort of patients. |
format | Online Article Text |
id | pubmed-6407102 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-64071022019-03-19 The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock Castello, Luigi Mario Baldrighi, Marco Molinari, Luca Salmi, Livia Cantaluppi, Vincenzo Vaschetto, Rosanna Zunino, Greta Quaglia, Marco Bellan, Mattia Gavelli, Francesco Navalesi, Paolo Avanzi, Gian Carlo Chiocchetti, Annalisa Cells Article Sepsis is a life-threatening organ dysfunction caused by a dysregulated host-response to infections. Osteopontin (OPN) is an extracellular matrix protein involved in the inflammatory response. Our aim was to evaluate the diagnostic and prognostic performance in sepsis of a single OPN determination in the Emergency Department (ED). We conducted a single-centre prospective observational study in an Italian ED where we enrolled 102 consecutive patients presenting with suspected infection and qSOFA ≥ 2. OPN plasma concentration was found to be an independent predictor of sepsis (OR = 1.020, 95% CI 1.002–1.039, p = 0.031) and the diagnostic receiver operating characteristic (ROC) curve resulted in an area under the curve (AUC) of 0.878. OPN levels were positively correlated to plasma creatinine (r = 0.401 with p = 0.0001), but this relation was not explained by the development of acute kidney injury (AKI), since no difference was found in OPN concentration between AKI and non-AKI patients. The analysis of 30-days mortality showed no significant difference in OPN levels between alive and dead patients (p = 0.482). In conclusion, a single determination of OPN concentration helped to identify patients with sepsis in the ED, but it was not able to predict poor prognosis in our cohort of patients. MDPI 2019-02-18 /pmc/articles/PMC6407102/ /pubmed/30781721 http://dx.doi.org/10.3390/cells8020174 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Castello, Luigi Mario Baldrighi, Marco Molinari, Luca Salmi, Livia Cantaluppi, Vincenzo Vaschetto, Rosanna Zunino, Greta Quaglia, Marco Bellan, Mattia Gavelli, Francesco Navalesi, Paolo Avanzi, Gian Carlo Chiocchetti, Annalisa The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock |
title | The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock |
title_full | The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock |
title_fullStr | The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock |
title_full_unstemmed | The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock |
title_short | The Role of Osteopontin as a Diagnostic and Prognostic Biomarker in Sepsis and Septic Shock |
title_sort | role of osteopontin as a diagnostic and prognostic biomarker in sepsis and septic shock |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407102/ https://www.ncbi.nlm.nih.gov/pubmed/30781721 http://dx.doi.org/10.3390/cells8020174 |
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