A High-Calorie Diet Aggravates Mitochondrial Dysfunction and Triggers Severe Liver Damage in Wilson Disease Rats

BACKGROUND & AIMS: In Wilson disease, ATP7B mutations impair copper excretion into bile. Hepatic copper accumulation may induce mild to moderate chronic liver damage or even acute liver failure. Etiologic factors for this heterogeneous phenotype remain enigmatic. Liver steatosis is a frequent fi...

Descripción completa

Detalles Bibliográficos
Autores principales: Einer, Claudia, Leitzinger, Christin, Lichtmannegger, Josef, Eberhagen, Carola, Rieder, Tamara, Borchard, Sabine, Wimmer, Ralf, Denk, Gerald, Popper, Bastian, Neff, Frauke, Polishchuk, Elena V., Polishchuk, Roman S., Hauck, Stefanie M., von Toerne, Christine, Müller, Jennifer-Christin, Karst, Uwe, Baral, Bipin S., DiSpirito, Alan A., Kremer, Andreas E., Semrau, Jeremy, Weiss, Karl Heinz, Hohenester, Simon, Zischka, Hans
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407159/
https://www.ncbi.nlm.nih.gov/pubmed/30586623
http://dx.doi.org/10.1016/j.jcmgh.2018.12.005

Ejemplares similares

Ejemplares similares