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C679X loss-of-function PCSK9 variant is associated with lower fasting glucose in black South African adolescents: Birth to Twenty Plus Cohort

AIM: To evaluate the association between loss-of-function (LOF) PCSK9 variants (A433T/rs28362263 and C679X/rs28362286) and biomarkers of cardiometabolic risk, specifically fasting glucose and low density lipoprotein cholesterol (LDL-C) concentrations. METHODS: Our study comprised 757 male and female...

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Detalles Bibliográficos
Autores principales:	Chikowore, Tinashe, Sahibdeen, Venesa, Hendry, Liesl M., Norris, Shane A., Goedecke, Julia H., Micklesfield, Lisa K., Lombard, Zané
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407309/ https://www.ncbi.nlm.nih.gov/pubmed/30899674 http://dx.doi.org/10.1016/j.jcte.2019.100186

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