The role of C16:0 ceramide in the development of obesity and type 2 diabetes: CerS6 inhibition as a novel therapeutic approach

OBJECTIVE: Ectopic fat deposition is associated with increased tissue production of ceramides. Recent genetic mouse studies suggest that specific sphingolipid C16:0 ceramide produced by ceramide synthase 6 (CerS6) plays an important role in the development of insulin resistance. However, the therape...

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Detalles Bibliográficos
Autores principales: Raichur, Suryaprakash, Brunner, Bodo, Bielohuby, Maximilian, Hansen, Gitte, Pfenninger, Anja, Wang, Bing, Bruning, Jens C., Larsen, Philip Just, Tennagels, Norbert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407366/
https://www.ncbi.nlm.nih.gov/pubmed/30655217
http://dx.doi.org/10.1016/j.molmet.2018.12.008

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