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Diagnostic applications for Lassa fever in limited-resource settings

Lassa fever, caused by arenavirus Lassa virus (LASV), is an acute viral haemorrhagic disease that affects up to an estimated 300 000 individuals and causes up to 5000 deaths per year in West Africa. Currently available LASV diagnostic methods are difficult to operationalise in low-resource health ce...

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Autores principales: Emperador, Devy M, Yimer, Solomon A, Mazzola, Laura T, Norheim, Gunnstein, Kelly-Cirino, Cassandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407552/
https://www.ncbi.nlm.nih.gov/pubmed/30899576
http://dx.doi.org/10.1136/bmjgh-2018-001119
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author Emperador, Devy M
Yimer, Solomon A
Mazzola, Laura T
Norheim, Gunnstein
Kelly-Cirino, Cassandra
author_facet Emperador, Devy M
Yimer, Solomon A
Mazzola, Laura T
Norheim, Gunnstein
Kelly-Cirino, Cassandra
author_sort Emperador, Devy M
collection PubMed
description Lassa fever, caused by arenavirus Lassa virus (LASV), is an acute viral haemorrhagic disease that affects up to an estimated 300 000 individuals and causes up to 5000 deaths per year in West Africa. Currently available LASV diagnostic methods are difficult to operationalise in low-resource health centres and may be less sensitive to detecting all known or emerging LASV strains. To prioritise diagnostic development for LASV, we assessed the diagnostic applications for case detection, clinical management, surveillance, outbreak response, and therapeutic and vaccine development at various healthcare levels. Diagnostic development should prioritise point-of-care and near-patient diagnostics, especially those with the ability to detect all lineages of LASV, as they would allow for rapid detection in resource-limited health facilities closer to the patient.
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spelling pubmed-64075522019-03-21 Diagnostic applications for Lassa fever in limited-resource settings Emperador, Devy M Yimer, Solomon A Mazzola, Laura T Norheim, Gunnstein Kelly-Cirino, Cassandra BMJ Glob Health Analysis Lassa fever, caused by arenavirus Lassa virus (LASV), is an acute viral haemorrhagic disease that affects up to an estimated 300 000 individuals and causes up to 5000 deaths per year in West Africa. Currently available LASV diagnostic methods are difficult to operationalise in low-resource health centres and may be less sensitive to detecting all known or emerging LASV strains. To prioritise diagnostic development for LASV, we assessed the diagnostic applications for case detection, clinical management, surveillance, outbreak response, and therapeutic and vaccine development at various healthcare levels. Diagnostic development should prioritise point-of-care and near-patient diagnostics, especially those with the ability to detect all lineages of LASV, as they would allow for rapid detection in resource-limited health facilities closer to the patient. BMJ Publishing Group 2019-02-07 /pmc/articles/PMC6407552/ /pubmed/30899576 http://dx.doi.org/10.1136/bmjgh-2018-001119 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: http://creativecommons.org/licenses/by/4.0
spellingShingle Analysis
Emperador, Devy M
Yimer, Solomon A
Mazzola, Laura T
Norheim, Gunnstein
Kelly-Cirino, Cassandra
Diagnostic applications for Lassa fever in limited-resource settings
title Diagnostic applications for Lassa fever in limited-resource settings
title_full Diagnostic applications for Lassa fever in limited-resource settings
title_fullStr Diagnostic applications for Lassa fever in limited-resource settings
title_full_unstemmed Diagnostic applications for Lassa fever in limited-resource settings
title_short Diagnostic applications for Lassa fever in limited-resource settings
title_sort diagnostic applications for lassa fever in limited-resource settings
topic Analysis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407552/
https://www.ncbi.nlm.nih.gov/pubmed/30899576
http://dx.doi.org/10.1136/bmjgh-2018-001119
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