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Diagnostic applications for Lassa fever in limited-resource settings
Lassa fever, caused by arenavirus Lassa virus (LASV), is an acute viral haemorrhagic disease that affects up to an estimated 300 000 individuals and causes up to 5000 deaths per year in West Africa. Currently available LASV diagnostic methods are difficult to operationalise in low-resource health ce...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BMJ Publishing Group
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407552/ https://www.ncbi.nlm.nih.gov/pubmed/30899576 http://dx.doi.org/10.1136/bmjgh-2018-001119 |
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author | Emperador, Devy M Yimer, Solomon A Mazzola, Laura T Norheim, Gunnstein Kelly-Cirino, Cassandra |
author_facet | Emperador, Devy M Yimer, Solomon A Mazzola, Laura T Norheim, Gunnstein Kelly-Cirino, Cassandra |
author_sort | Emperador, Devy M |
collection | PubMed |
description | Lassa fever, caused by arenavirus Lassa virus (LASV), is an acute viral haemorrhagic disease that affects up to an estimated 300 000 individuals and causes up to 5000 deaths per year in West Africa. Currently available LASV diagnostic methods are difficult to operationalise in low-resource health centres and may be less sensitive to detecting all known or emerging LASV strains. To prioritise diagnostic development for LASV, we assessed the diagnostic applications for case detection, clinical management, surveillance, outbreak response, and therapeutic and vaccine development at various healthcare levels. Diagnostic development should prioritise point-of-care and near-patient diagnostics, especially those with the ability to detect all lineages of LASV, as they would allow for rapid detection in resource-limited health facilities closer to the patient. |
format | Online Article Text |
id | pubmed-6407552 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | BMJ Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-64075522019-03-21 Diagnostic applications for Lassa fever in limited-resource settings Emperador, Devy M Yimer, Solomon A Mazzola, Laura T Norheim, Gunnstein Kelly-Cirino, Cassandra BMJ Glob Health Analysis Lassa fever, caused by arenavirus Lassa virus (LASV), is an acute viral haemorrhagic disease that affects up to an estimated 300 000 individuals and causes up to 5000 deaths per year in West Africa. Currently available LASV diagnostic methods are difficult to operationalise in low-resource health centres and may be less sensitive to detecting all known or emerging LASV strains. To prioritise diagnostic development for LASV, we assessed the diagnostic applications for case detection, clinical management, surveillance, outbreak response, and therapeutic and vaccine development at various healthcare levels. Diagnostic development should prioritise point-of-care and near-patient diagnostics, especially those with the ability to detect all lineages of LASV, as they would allow for rapid detection in resource-limited health facilities closer to the patient. BMJ Publishing Group 2019-02-07 /pmc/articles/PMC6407552/ /pubmed/30899576 http://dx.doi.org/10.1136/bmjgh-2018-001119 Text en © Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Analysis Emperador, Devy M Yimer, Solomon A Mazzola, Laura T Norheim, Gunnstein Kelly-Cirino, Cassandra Diagnostic applications for Lassa fever in limited-resource settings |
title | Diagnostic applications for Lassa fever in limited-resource settings |
title_full | Diagnostic applications for Lassa fever in limited-resource settings |
title_fullStr | Diagnostic applications for Lassa fever in limited-resource settings |
title_full_unstemmed | Diagnostic applications for Lassa fever in limited-resource settings |
title_short | Diagnostic applications for Lassa fever in limited-resource settings |
title_sort | diagnostic applications for lassa fever in limited-resource settings |
topic | Analysis |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407552/ https://www.ncbi.nlm.nih.gov/pubmed/30899576 http://dx.doi.org/10.1136/bmjgh-2018-001119 |
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