mTOR inhibition affects Yap1-β-catenin-induced hepatoblastoma growth and development

Hepatoblastoma (HB) is the most common pediatric liver malignancy. Around 80% of HB demonstrate simultaneous activation of β-catenin and Yes-associated protein 1 (Yap1). The mechanism by which these signaling pathways contribute to HB pathogenesis remain obscure. Recently, mTORC1 activation was repo...

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Detalles Bibliográficos
Autores principales: Molina, Laura, Yang, Hong, Adebayo Michael, Adeola O., Oertel, Michael, Bell, Aaron, Singh, Sucha, Chen, Xin, Tao, Junyan, Monga, Satdarshan P.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2019
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407673/
https://www.ncbi.nlm.nih.gov/pubmed/30863496
http://dx.doi.org/10.18632/oncotarget.26668

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407673/
https://www.ncbi.nlm.nih.gov/pubmed/30863496
http://dx.doi.org/10.18632/oncotarget.26668

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