Is there a reliable size cut-off for splenic involvement in lymphoma? A [18F]FDG-PET controlled study

PURPOSE: Aim of present study was to determine whether the currently recommended 13-cm cranio-caudal diameter cut-off on CT for assessment of splenic involvement in lymphoma offers adequate sensitivity and specificity. MATERIALS AND METHODS: Patients with histologically proven lymphoma who had under...

Descripción completa

Detalles Bibliográficos
Autores principales: Berzaczy, Dominik, Haug, Alexander R., Raderer, Markus, Kiesewetter, Barbara, Berzaczy, Gundula, Weber, Michael, Mayerhoefer, Marius E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407760/
https://www.ncbi.nlm.nih.gov/pubmed/30849131
http://dx.doi.org/10.1371/journal.pone.0213551
Descripción
Sumario:PURPOSE: Aim of present study was to determine whether the currently recommended 13-cm cranio-caudal diameter cut-off on CT for assessment of splenic involvement in lymphoma offers adequate sensitivity and specificity. MATERIALS AND METHODS: Patients with histologically proven lymphoma who had undergone [18F]FDG-PET/CT before therapy were included. Cranio-caudal diameters of the spleen were measured on the CT component of PET/CT, and ROC analyses with calculation of respective areas under the curve (AUC) were used to determine cut-off values of cranio-caudal measurements with their respective sensitivities and specificities, using [18F]FDG-PET as the reference standard. RESULTS: In 93 patients, we found a sensitivity of 74.1% and a specificity of 47% for the 13-cm splenic diameter cut-off. CONCLUSIONS: Our results show reasonable, though far from perfect sensitivities and specificities for the currently recommend 13-cm splenic diameter cut-off.

Ejemplares similares