DREADD Agonist 21 Is an Effective Agonist for Muscarinic-Based DREADDs in Vitro and in Vivo

[Image: see text] Chemogenetic tools such as designer receptors exclusively activated by designer drugs (DREADDs) are routinely used to modulate neuronal and non-neuronal signaling and activity in a relatively noninvasive manner. The first generation of DREADDs were templated from the human muscarin...

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Detalles Bibliográficos
Autores principales: Thompson, Karen J., Khajehali, Elham, Bradley, Sophie J., Navarrete, Jovana S., Huang, Xi Ping, Slocum, Samuel, Jin, Jian, Liu, Jing, Xiong, Yan, Olsen, Reid H. J., Diberto, Jeffrey F., Boyt, Kristen M., Pina, Melanie M., Pati, Dipanwita, Molloy, Colin, Bundgaard, Christoffer, Sexton, Patrick M., Kash, Thomas L., Krashes, Michael J., Christopoulos, Arthur, Roth, Bryan L., Tobin, Andrew B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2018
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407913/
https://www.ncbi.nlm.nih.gov/pubmed/30868140
http://dx.doi.org/10.1021/acsptsci.8b00012

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