Cargando…
A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: Neutrophil lymphocyte ratio/prealbumin ratio
NLR/Alb (neutrophil lymphocyte ratio/albumin ratio), is a prognostic index for esophageal cancer has been confirmed. Prealbumin (PA) is more sensitive to malnutrition than albumin. A new prognostic index, named neutrophil lymphocyte ratio/prealbumin ratio (NLR/PA), for predicting the survival time i...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407987/ https://www.ncbi.nlm.nih.gov/pubmed/30762804 http://dx.doi.org/10.1097/MD.0000000000014562 |
_version_ | 1783401672490352640 |
---|---|
author | Lv, Yajuan Zhang, Jiandong Liu, Zhen Tian, Yuan Liu, Fengjun |
author_facet | Lv, Yajuan Zhang, Jiandong Liu, Zhen Tian, Yuan Liu, Fengjun |
author_sort | Lv, Yajuan |
collection | PubMed |
description | NLR/Alb (neutrophil lymphocyte ratio/albumin ratio), is a prognostic index for esophageal cancer has been confirmed. Prealbumin (PA) is more sensitive to malnutrition than albumin. A new prognostic index, named neutrophil lymphocyte ratio/prealbumin ratio (NLR/PA), for predicting the survival time in patients with esophageal squamous cell carcinoma (ESCC) was proposed. A retrospective study of 315 cases with ESCC was enrolled. The optimal cut-off values were evaluated by ROC curve (the receiver operating characteristics curve). Pearson correlation analyses were used to calculate the correlations among NLR, Alb, NLR/Alb and NLR/PA. The overall survival (OS) was calculated by Kaplan-Meier method. Cox regression analyses were performed to evaluate the prognostic factors. The optimal cut-off value was 0.01 for NLR/PA according to ROC curve. According to multivariate analyses, TNM stage, NLR, NLR/Alb, NLR/PA were prognostic factors for OS. The AUC area (the area under the receiver operating characteristics curves) of the NLR/PA was higher than the areas of NLR and NLR/Alb for all the patients. The index of NLR/ PA had a higher AUC area than that of the index of NLR or NLR/Alb for patients in stage I-II. But in stage III-IVA, the index of NLR had a higher AUC area than that of the index of NLR/PA or NLR/Alb. The index of NLR/PA is superior to the index of NLR as a prognostic indicator for patients with early stage (stage I-II) ESCC. |
format | Online Article Text |
id | pubmed-6407987 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-64079872019-03-16 A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: Neutrophil lymphocyte ratio/prealbumin ratio Lv, Yajuan Zhang, Jiandong Liu, Zhen Tian, Yuan Liu, Fengjun Medicine (Baltimore) Research Article NLR/Alb (neutrophil lymphocyte ratio/albumin ratio), is a prognostic index for esophageal cancer has been confirmed. Prealbumin (PA) is more sensitive to malnutrition than albumin. A new prognostic index, named neutrophil lymphocyte ratio/prealbumin ratio (NLR/PA), for predicting the survival time in patients with esophageal squamous cell carcinoma (ESCC) was proposed. A retrospective study of 315 cases with ESCC was enrolled. The optimal cut-off values were evaluated by ROC curve (the receiver operating characteristics curve). Pearson correlation analyses were used to calculate the correlations among NLR, Alb, NLR/Alb and NLR/PA. The overall survival (OS) was calculated by Kaplan-Meier method. Cox regression analyses were performed to evaluate the prognostic factors. The optimal cut-off value was 0.01 for NLR/PA according to ROC curve. According to multivariate analyses, TNM stage, NLR, NLR/Alb, NLR/PA were prognostic factors for OS. The AUC area (the area under the receiver operating characteristics curves) of the NLR/PA was higher than the areas of NLR and NLR/Alb for all the patients. The index of NLR/ PA had a higher AUC area than that of the index of NLR or NLR/Alb for patients in stage I-II. But in stage III-IVA, the index of NLR had a higher AUC area than that of the index of NLR/PA or NLR/Alb. The index of NLR/PA is superior to the index of NLR as a prognostic indicator for patients with early stage (stage I-II) ESCC. Wolters Kluwer Health 2019-02-15 /pmc/articles/PMC6407987/ /pubmed/30762804 http://dx.doi.org/10.1097/MD.0000000000014562 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | Research Article Lv, Yajuan Zhang, Jiandong Liu, Zhen Tian, Yuan Liu, Fengjun A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: Neutrophil lymphocyte ratio/prealbumin ratio |
title | A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: Neutrophil lymphocyte ratio/prealbumin ratio |
title_full | A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: Neutrophil lymphocyte ratio/prealbumin ratio |
title_fullStr | A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: Neutrophil lymphocyte ratio/prealbumin ratio |
title_full_unstemmed | A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: Neutrophil lymphocyte ratio/prealbumin ratio |
title_short | A novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: Neutrophil lymphocyte ratio/prealbumin ratio |
title_sort | novel inflammation-based prognostic index for patients with esophageal squamous cell carcinoma: neutrophil lymphocyte ratio/prealbumin ratio |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6407987/ https://www.ncbi.nlm.nih.gov/pubmed/30762804 http://dx.doi.org/10.1097/MD.0000000000014562 |
work_keys_str_mv | AT lvyajuan anovelinflammationbasedprognosticindexforpatientswithesophagealsquamouscellcarcinomaneutrophillymphocyteratioprealbuminratio AT zhangjiandong anovelinflammationbasedprognosticindexforpatientswithesophagealsquamouscellcarcinomaneutrophillymphocyteratioprealbuminratio AT liuzhen anovelinflammationbasedprognosticindexforpatientswithesophagealsquamouscellcarcinomaneutrophillymphocyteratioprealbuminratio AT tianyuan anovelinflammationbasedprognosticindexforpatientswithesophagealsquamouscellcarcinomaneutrophillymphocyteratioprealbuminratio AT liufengjun anovelinflammationbasedprognosticindexforpatientswithesophagealsquamouscellcarcinomaneutrophillymphocyteratioprealbuminratio AT lvyajuan novelinflammationbasedprognosticindexforpatientswithesophagealsquamouscellcarcinomaneutrophillymphocyteratioprealbuminratio AT zhangjiandong novelinflammationbasedprognosticindexforpatientswithesophagealsquamouscellcarcinomaneutrophillymphocyteratioprealbuminratio AT liuzhen novelinflammationbasedprognosticindexforpatientswithesophagealsquamouscellcarcinomaneutrophillymphocyteratioprealbuminratio AT tianyuan novelinflammationbasedprognosticindexforpatientswithesophagealsquamouscellcarcinomaneutrophillymphocyteratioprealbuminratio AT liufengjun novelinflammationbasedprognosticindexforpatientswithesophagealsquamouscellcarcinomaneutrophillymphocyteratioprealbuminratio |