Cargando…
Risk of subsequent health disorders among living kidney donors
Few studies have investigated the risk of physiological sequelae in living kidney donors (KDs). We conducted a population-based cohort study using the National Health Insurance Research Database of Taiwan, which covers more than 99% of citizens. We comprehensively investigated the risk of medical di...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408042/ https://www.ncbi.nlm.nih.gov/pubmed/30762774 http://dx.doi.org/10.1097/MD.0000000000014494 |
_version_ | 1783401687413686272 |
---|---|
author | Lin, Shih-Yi Lin, Cheng-Li Sung, Fung-Chang Chang, Chao-Hsiang Wu, His-Chin Chen, Wen-Chi Wang, I-Kuan Chen, Chao-Jung Chou, An-Kuo Kao, Chia-Hung |
author_facet | Lin, Shih-Yi Lin, Cheng-Li Sung, Fung-Chang Chang, Chao-Hsiang Wu, His-Chin Chen, Wen-Chi Wang, I-Kuan Chen, Chao-Jung Chou, An-Kuo Kao, Chia-Hung |
author_sort | Lin, Shih-Yi |
collection | PubMed |
description | Few studies have investigated the risk of physiological sequelae in living kidney donors (KDs). We conducted a population-based cohort study using the National Health Insurance Research Database of Taiwan, which covers more than 99% of citizens. We comprehensively investigated the risk of medical disorders after kidney donation in living KDs using a maximum follow-up of 13 years. From January 1997 to December 2010, 1081 living KDs and 1082 age- and sex-matched non-KDs were eligible. Primary outcomes comprised end-stage renal disease, chronic kidney disease, stroke, cancer, acute myocardial infarction, acute renal failure (ARF), and diabetes. The adjusted hazard ratios (HRs) for developing ARF, diabetes, hyperlipidemia, hypertension, cancer, end-stage renal disease, acute myocardial infarction, and stroke were similar between the KD and non-KD cohorts (P > .05). Although differences in the adjusted HRs of ARF were nonsignificant, the cumulative incidence rate of ARF 13 years after donation was 7.48 per 1000 person-years in the KD cohort compared with 3.46 in the matched non-KD cohort. The incidence rate ratio for ARF between donors and nondonors significantly increased to 2.16 (95% confidence interval, 1.61–2.71). Living KDs experienced no significant health disorders following kidney donation but should be alert to the higher incidence rate of ARF. |
format | Online Article Text |
id | pubmed-6408042 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-64080422019-03-16 Risk of subsequent health disorders among living kidney donors Lin, Shih-Yi Lin, Cheng-Li Sung, Fung-Chang Chang, Chao-Hsiang Wu, His-Chin Chen, Wen-Chi Wang, I-Kuan Chen, Chao-Jung Chou, An-Kuo Kao, Chia-Hung Medicine (Baltimore) Research Article Few studies have investigated the risk of physiological sequelae in living kidney donors (KDs). We conducted a population-based cohort study using the National Health Insurance Research Database of Taiwan, which covers more than 99% of citizens. We comprehensively investigated the risk of medical disorders after kidney donation in living KDs using a maximum follow-up of 13 years. From January 1997 to December 2010, 1081 living KDs and 1082 age- and sex-matched non-KDs were eligible. Primary outcomes comprised end-stage renal disease, chronic kidney disease, stroke, cancer, acute myocardial infarction, acute renal failure (ARF), and diabetes. The adjusted hazard ratios (HRs) for developing ARF, diabetes, hyperlipidemia, hypertension, cancer, end-stage renal disease, acute myocardial infarction, and stroke were similar between the KD and non-KD cohorts (P > .05). Although differences in the adjusted HRs of ARF were nonsignificant, the cumulative incidence rate of ARF 13 years after donation was 7.48 per 1000 person-years in the KD cohort compared with 3.46 in the matched non-KD cohort. The incidence rate ratio for ARF between donors and nondonors significantly increased to 2.16 (95% confidence interval, 1.61–2.71). Living KDs experienced no significant health disorders following kidney donation but should be alert to the higher incidence rate of ARF. Wolters Kluwer Health 2019-02-15 /pmc/articles/PMC6408042/ /pubmed/30762774 http://dx.doi.org/10.1097/MD.0000000000014494 Text en Copyright © 2019 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Research Article Lin, Shih-Yi Lin, Cheng-Li Sung, Fung-Chang Chang, Chao-Hsiang Wu, His-Chin Chen, Wen-Chi Wang, I-Kuan Chen, Chao-Jung Chou, An-Kuo Kao, Chia-Hung Risk of subsequent health disorders among living kidney donors |
title | Risk of subsequent health disorders among living kidney donors |
title_full | Risk of subsequent health disorders among living kidney donors |
title_fullStr | Risk of subsequent health disorders among living kidney donors |
title_full_unstemmed | Risk of subsequent health disorders among living kidney donors |
title_short | Risk of subsequent health disorders among living kidney donors |
title_sort | risk of subsequent health disorders among living kidney donors |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408042/ https://www.ncbi.nlm.nih.gov/pubmed/30762774 http://dx.doi.org/10.1097/MD.0000000000014494 |
work_keys_str_mv | AT linshihyi riskofsubsequenthealthdisordersamonglivingkidneydonors AT linchengli riskofsubsequenthealthdisordersamonglivingkidneydonors AT sungfungchang riskofsubsequenthealthdisordersamonglivingkidneydonors AT changchaohsiang riskofsubsequenthealthdisordersamonglivingkidneydonors AT wuhischin riskofsubsequenthealthdisordersamonglivingkidneydonors AT chenwenchi riskofsubsequenthealthdisordersamonglivingkidneydonors AT wangikuan riskofsubsequenthealthdisordersamonglivingkidneydonors AT chenchaojung riskofsubsequenthealthdisordersamonglivingkidneydonors AT chouankuo riskofsubsequenthealthdisordersamonglivingkidneydonors AT kaochiahung riskofsubsequenthealthdisordersamonglivingkidneydonors |