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The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1–associated myelopathy (HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and renal transplantation
Because there are limited clinical reports on the impact of human T-lymphotropic virus type 1 (HTLV-1) on organ transplantation, its effects on the development of adult T-cell leukemia-lymphoma (ATL), post-transplantation lymphoproliferative disorder (PTLD) and HTLV-1–associated myelopathy (HAM) or...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JSLRT
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408177/ https://www.ncbi.nlm.nih.gov/pubmed/30089749 http://dx.doi.org/10.3960/jslrt.18011 |
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author | Kawano, Noriaki Yoshida, Shuro Kawano, Sayaka Kuriyama, Takuro Tahara, Yoshihiro Toyofuku, Atsushi Manabe, Tatsuya Doi, Atsushi Terasaka, Soushi Yamashita, Kiyoshi Ueda, Yuji Ochiai, Hidenobu Marutsuka, Kousuke Yamano, Yoshihisa Shimoda, Kazuya Kikuchi, Ikuo |
author_facet | Kawano, Noriaki Yoshida, Shuro Kawano, Sayaka Kuriyama, Takuro Tahara, Yoshihiro Toyofuku, Atsushi Manabe, Tatsuya Doi, Atsushi Terasaka, Soushi Yamashita, Kiyoshi Ueda, Yuji Ochiai, Hidenobu Marutsuka, Kousuke Yamano, Yoshihisa Shimoda, Kazuya Kikuchi, Ikuo |
author_sort | Kawano, Noriaki |
collection | PubMed |
description | Because there are limited clinical reports on the impact of human T-lymphotropic virus type 1 (HTLV-1) on organ transplantation, its effects on the development of adult T-cell leukemia-lymphoma (ATL), post-transplantation lymphoproliferative disorder (PTLD) and HTLV-1–associated myelopathy (HAM) or atypical HAM after organ transplantation remain unclear. We retrospectively analyzed the impact of HTLV-1 in 54 allogeneic hematopoietic stem cell transplantation (allo-HSCT) cases and 31 renal transplantation cases between January 2006 and December 2016. Among the 54 allo-HSCT cases, nine recipients with ATL tested positive for HTLV-1, and one was found to be an HTLV-1 carrier. All donors tested negative for HTLV-1. Only one HTLV-1 carrier did not present with ATL or HAM development after allo-HSCT. Among nine ATL cases after allo-HSCT, four eventually relapsed due to proliferation of recipient-derived ATL cells. However, in one ATL case, atypical HAM developed rapidly at 5 months after allo-HSCT. Among the 31 renal transplantation cases, all donors tested negative for HTLV-1, and only recipients tested positive. Only one HTLV-1 carrier recipient did not present with ATL or HAM development after renal transplantation. However, one HTLV-1-negative recipient developed PTLD in the brain 10 years after renal transplantation. In clinical practice, careful follow-up of HTLV-1 infected recipients after organ transplantation is important because atypical HAM can develop in ATL patients after allo-HSCT. Furthermore, to clarify the risk of ATL or HAM development in HTLV-1 infected recipients, we prospectively followed up our cohort. |
format | Online Article Text |
id | pubmed-6408177 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | JSLRT |
record_format | MEDLINE/PubMed |
spelling | pubmed-64081772019-05-29 The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1–associated myelopathy (HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and renal transplantation Kawano, Noriaki Yoshida, Shuro Kawano, Sayaka Kuriyama, Takuro Tahara, Yoshihiro Toyofuku, Atsushi Manabe, Tatsuya Doi, Atsushi Terasaka, Soushi Yamashita, Kiyoshi Ueda, Yuji Ochiai, Hidenobu Marutsuka, Kousuke Yamano, Yoshihisa Shimoda, Kazuya Kikuchi, Ikuo J Clin Exp Hematop Original Article Because there are limited clinical reports on the impact of human T-lymphotropic virus type 1 (HTLV-1) on organ transplantation, its effects on the development of adult T-cell leukemia-lymphoma (ATL), post-transplantation lymphoproliferative disorder (PTLD) and HTLV-1–associated myelopathy (HAM) or atypical HAM after organ transplantation remain unclear. We retrospectively analyzed the impact of HTLV-1 in 54 allogeneic hematopoietic stem cell transplantation (allo-HSCT) cases and 31 renal transplantation cases between January 2006 and December 2016. Among the 54 allo-HSCT cases, nine recipients with ATL tested positive for HTLV-1, and one was found to be an HTLV-1 carrier. All donors tested negative for HTLV-1. Only one HTLV-1 carrier did not present with ATL or HAM development after allo-HSCT. Among nine ATL cases after allo-HSCT, four eventually relapsed due to proliferation of recipient-derived ATL cells. However, in one ATL case, atypical HAM developed rapidly at 5 months after allo-HSCT. Among the 31 renal transplantation cases, all donors tested negative for HTLV-1, and only recipients tested positive. Only one HTLV-1 carrier recipient did not present with ATL or HAM development after renal transplantation. However, one HTLV-1-negative recipient developed PTLD in the brain 10 years after renal transplantation. In clinical practice, careful follow-up of HTLV-1 infected recipients after organ transplantation is important because atypical HAM can develop in ATL patients after allo-HSCT. Furthermore, to clarify the risk of ATL or HAM development in HTLV-1 infected recipients, we prospectively followed up our cohort. JSLRT 2018-08-08 /pmc/articles/PMC6408177/ /pubmed/30089749 http://dx.doi.org/10.3960/jslrt.18011 Text en © 2018 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License. |
spellingShingle | Original Article Kawano, Noriaki Yoshida, Shuro Kawano, Sayaka Kuriyama, Takuro Tahara, Yoshihiro Toyofuku, Atsushi Manabe, Tatsuya Doi, Atsushi Terasaka, Soushi Yamashita, Kiyoshi Ueda, Yuji Ochiai, Hidenobu Marutsuka, Kousuke Yamano, Yoshihisa Shimoda, Kazuya Kikuchi, Ikuo The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1–associated myelopathy (HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT) and renal transplantation |
title | The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection
on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1–associated myelopathy
(HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
and renal transplantation |
title_full | The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection
on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1–associated myelopathy
(HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
and renal transplantation |
title_fullStr | The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection
on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1–associated myelopathy
(HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
and renal transplantation |
title_full_unstemmed | The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection
on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1–associated myelopathy
(HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
and renal transplantation |
title_short | The clinical impact of human T-lymphotrophic virus type 1 (HTLV-1) infection
on the development of adult T-cell leukemia-lymphoma (ATL) or HTLV-1–associated myelopathy
(HAM) / atypical HAM after allogeneic hematopoietic stem cell transplantation (allo-HSCT)
and renal transplantation |
title_sort | clinical impact of human t-lymphotrophic virus type 1 (htlv-1) infection
on the development of adult t-cell leukemia-lymphoma (atl) or htlv-1–associated myelopathy
(ham) / atypical ham after allogeneic hematopoietic stem cell transplantation (allo-hsct)
and renal transplantation |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408177/ https://www.ncbi.nlm.nih.gov/pubmed/30089749 http://dx.doi.org/10.3960/jslrt.18011 |
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