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Characteristic Histological Findings of Asymptomatic EBV-associated Lymphoproliferative Disorders in Tonsils
Recently, an in situ hybridization (ISH) and immunohistochemical study demonstrated that Epstein-Barr virus (EBV) infection may be involved in tonsillar hypertrophy and recurrent tonsillitis in children and young adolescents. The present study was based on 630 consecutive specimens from tonsillectom...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
JSLRT
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408178/ https://www.ncbi.nlm.nih.gov/pubmed/30012922 http://dx.doi.org/10.3960/jslrt.18017 |
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author | Jamiyan, Tsengelmaa Nakazato, Yoshimasa Kuroda, Hajime Kojima, Masaru Imai, Yasuo |
author_facet | Jamiyan, Tsengelmaa Nakazato, Yoshimasa Kuroda, Hajime Kojima, Masaru Imai, Yasuo |
author_sort | Jamiyan, Tsengelmaa |
collection | PubMed |
description | Recently, an in situ hybridization (ISH) and immunohistochemical study demonstrated that Epstein-Barr virus (EBV) infection may be involved in tonsillar hypertrophy and recurrent tonsillitis in children and young adolescents. The present study was based on 630 consecutive specimens from tonsillectomies performed at the Dokkyo University School of Medicine between 2002 and May 2017. Clinical findings were obtained from hospital records. Histologically, a “pale clear zone” was characterized by hyperplastic germinal centers with ill-defined borders and interfollicular expansion. Immunohistologically, the majority of immunoblasts were CD20-positive, whereas medium to large lymphoid cells usually expressed CD3. Among 14 lesions, numerous EBV-encoded small RNA (EBER)-positive cells were detected in 10. In 7 of these 10 lesions, EBER-positive cells were detected in germinal centers as well as in the interfollicular area. Based on our results, the “pale clear zone” suggests asymptomatic EBV infection of the tonsil. The present study demonstrated that “pale clear zones” should be taken into consideration when diagnosing asymptomatic EBV-associated LPDs in the tonsils of children and young adolescents as well as in middle-aged patients. |
format | Online Article Text |
id | pubmed-6408178 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | JSLRT |
record_format | MEDLINE/PubMed |
spelling | pubmed-64081782019-05-29 Characteristic Histological Findings of Asymptomatic EBV-associated Lymphoproliferative Disorders in Tonsils Jamiyan, Tsengelmaa Nakazato, Yoshimasa Kuroda, Hajime Kojima, Masaru Imai, Yasuo J Clin Exp Hematop Original Article Recently, an in situ hybridization (ISH) and immunohistochemical study demonstrated that Epstein-Barr virus (EBV) infection may be involved in tonsillar hypertrophy and recurrent tonsillitis in children and young adolescents. The present study was based on 630 consecutive specimens from tonsillectomies performed at the Dokkyo University School of Medicine between 2002 and May 2017. Clinical findings were obtained from hospital records. Histologically, a “pale clear zone” was characterized by hyperplastic germinal centers with ill-defined borders and interfollicular expansion. Immunohistologically, the majority of immunoblasts were CD20-positive, whereas medium to large lymphoid cells usually expressed CD3. Among 14 lesions, numerous EBV-encoded small RNA (EBER)-positive cells were detected in 10. In 7 of these 10 lesions, EBER-positive cells were detected in germinal centers as well as in the interfollicular area. Based on our results, the “pale clear zone” suggests asymptomatic EBV infection of the tonsil. The present study demonstrated that “pale clear zones” should be taken into consideration when diagnosing asymptomatic EBV-associated LPDs in the tonsils of children and young adolescents as well as in middle-aged patients. JSLRT 2018-07-14 /pmc/articles/PMC6408178/ /pubmed/30012922 http://dx.doi.org/10.3960/jslrt.18017 Text en © 2018 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License. |
spellingShingle | Original Article Jamiyan, Tsengelmaa Nakazato, Yoshimasa Kuroda, Hajime Kojima, Masaru Imai, Yasuo Characteristic Histological Findings of Asymptomatic EBV-associated Lymphoproliferative Disorders in Tonsils |
title | Characteristic Histological Findings of Asymptomatic EBV-associated
Lymphoproliferative Disorders in Tonsils |
title_full | Characteristic Histological Findings of Asymptomatic EBV-associated
Lymphoproliferative Disorders in Tonsils |
title_fullStr | Characteristic Histological Findings of Asymptomatic EBV-associated
Lymphoproliferative Disorders in Tonsils |
title_full_unstemmed | Characteristic Histological Findings of Asymptomatic EBV-associated
Lymphoproliferative Disorders in Tonsils |
title_short | Characteristic Histological Findings of Asymptomatic EBV-associated
Lymphoproliferative Disorders in Tonsils |
title_sort | characteristic histological findings of asymptomatic ebv-associated
lymphoproliferative disorders in tonsils |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408178/ https://www.ncbi.nlm.nih.gov/pubmed/30012922 http://dx.doi.org/10.3960/jslrt.18017 |
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