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Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers
The liver plays a central role in metabolism; however, xenobiotic metabolism variations between human hepatocytes and those in model organisms create challenges in establishing functional test beds to detect the potential drug toxicity and efficacy of candidate small molecules. In the emerging areas...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cell Press
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408324/ https://www.ncbi.nlm.nih.gov/pubmed/30840913 http://dx.doi.org/10.1016/j.cmet.2019.02.003 |