GDF15 Provides an Endocrine Signal of Nutritional Stress in Mice and Humans

GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological role in energy balance. We performed experiments in humans, mice, and cells t...

Descripción completa

Detalles Bibliográficos
Autores principales: Patel, Satish, Alvarez-Guaita, Anna, Melvin, Audrey, Rimmington, Debra, Dattilo, Alessia, Miedzybrodzka, Emily L., Cimino, Irene, Maurin, Anne-Catherine, Roberts, Geoffrey P., Meek, Claire L., Virtue, Samuel, Sparks, Lauren M., Parsons, Stephanie A., Redman, Leanne M., Bray, George A., Liou, Alice P., Woods, Rachel M., Parry, Sion A., Jeppesen, Per B., Kolnes, Anders J., Harding, Heather P., Ron, David, Vidal-Puig, Antonio, Reimann, Frank, Gribble, Fiona M., Hulston, Carl J., Farooqi, I. Sadaf, Fafournoux, Pierre, Smith, Steven R., Jensen, Jorgen, Breen, Danna, Wu, Zhidan, Zhang, Bei B., Coll, Anthony P., Savage, David B., O’Rahilly, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408327/
https://www.ncbi.nlm.nih.gov/pubmed/30639358
http://dx.doi.org/10.1016/j.cmet.2018.12.016

Ejemplares similares

Ejemplares similares