Cholesterol Interaction Sites on the Transmembrane Domain of the Hedgehog Signal Transducer and Class F G Protein-Coupled Receptor Smoothened

Transduction of Hedgehog signals across the plasma membrane is facilitated by the class F G-protein-coupled-receptor (GPCR) Smoothened (SMO). Recent studies suggest that SMO is modulated via interactions of its transmembrane (TM) domain with cholesterol. We apply molecular dynamics simulations of SM...

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Detalles Bibliográficos
Autores principales: Hedger, George, Koldsø, Heidi, Chavent, Matthieu, Siebold, Christian, Rohatgi, Rajat, Sansom, Mark S.P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408332/
https://www.ncbi.nlm.nih.gov/pubmed/30595453
http://dx.doi.org/10.1016/j.str.2018.11.003

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408332/
https://www.ncbi.nlm.nih.gov/pubmed/30595453
http://dx.doi.org/10.1016/j.str.2018.11.003

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