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Phylogeny matters: revisiting ‘a comparison of bats and rodents as reservoirs of zoonotic viruses’
Diseases emerging from wildlife have been the source of many major human outbreaks. Predicting key sources of these outbreaks requires an understanding of the factors that explain pathogen diversity in reservoir species. Comparative methods are powerful tools for understanding variation in pathogen...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408376/ https://www.ncbi.nlm.nih.gov/pubmed/30891262 http://dx.doi.org/10.1098/rsos.181182 |
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author | Guy, Cylita Thiagavel, Jeneni Mideo, Nicole Ratcliffe, John M. |
author_facet | Guy, Cylita Thiagavel, Jeneni Mideo, Nicole Ratcliffe, John M. |
author_sort | Guy, Cylita |
collection | PubMed |
description | Diseases emerging from wildlife have been the source of many major human outbreaks. Predicting key sources of these outbreaks requires an understanding of the factors that explain pathogen diversity in reservoir species. Comparative methods are powerful tools for understanding variation in pathogen diversity and rely on correcting for phylogenetic relatedness among reservoir species. We reanalysed a previously published dataset, examining the relative effects of species' traits on patterns of viral diversity in bats and rodents. We expanded on prior work by using more highly resolved phylogenies for bats and rodents and incorporating a phylogenetically controlled principal components analysis. For rodents, sympatry and torpor use were important predictors of viral richness and, as previously reported, phylogeny had minimal impact in models. For bats, in contrast to prior work, we find that phylogeny does have an effect in models. Patterns of viral diversity in bats were related to geographical distribution (i.e. latitude and range size) and life history (i.e. lifespan, body size and birthing frequency). However, the effects of these predictors were marginal relative to citation count, emphasizing that the ability to accurately assess reservoir status largely depends on sampling effort and highlighting the need for additional data in future comparative studies. |
format | Online Article Text |
id | pubmed-6408376 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | The Royal Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-64083762019-03-19 Phylogeny matters: revisiting ‘a comparison of bats and rodents as reservoirs of zoonotic viruses’ Guy, Cylita Thiagavel, Jeneni Mideo, Nicole Ratcliffe, John M. R Soc Open Sci Biology (Whole Organism) Diseases emerging from wildlife have been the source of many major human outbreaks. Predicting key sources of these outbreaks requires an understanding of the factors that explain pathogen diversity in reservoir species. Comparative methods are powerful tools for understanding variation in pathogen diversity and rely on correcting for phylogenetic relatedness among reservoir species. We reanalysed a previously published dataset, examining the relative effects of species' traits on patterns of viral diversity in bats and rodents. We expanded on prior work by using more highly resolved phylogenies for bats and rodents and incorporating a phylogenetically controlled principal components analysis. For rodents, sympatry and torpor use were important predictors of viral richness and, as previously reported, phylogeny had minimal impact in models. For bats, in contrast to prior work, we find that phylogeny does have an effect in models. Patterns of viral diversity in bats were related to geographical distribution (i.e. latitude and range size) and life history (i.e. lifespan, body size and birthing frequency). However, the effects of these predictors were marginal relative to citation count, emphasizing that the ability to accurately assess reservoir status largely depends on sampling effort and highlighting the need for additional data in future comparative studies. The Royal Society 2019-02-13 /pmc/articles/PMC6408376/ /pubmed/30891262 http://dx.doi.org/10.1098/rsos.181182 Text en © 2019 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited. |
spellingShingle | Biology (Whole Organism) Guy, Cylita Thiagavel, Jeneni Mideo, Nicole Ratcliffe, John M. Phylogeny matters: revisiting ‘a comparison of bats and rodents as reservoirs of zoonotic viruses’ |
title | Phylogeny matters: revisiting ‘a comparison of bats and rodents as reservoirs of zoonotic viruses’ |
title_full | Phylogeny matters: revisiting ‘a comparison of bats and rodents as reservoirs of zoonotic viruses’ |
title_fullStr | Phylogeny matters: revisiting ‘a comparison of bats and rodents as reservoirs of zoonotic viruses’ |
title_full_unstemmed | Phylogeny matters: revisiting ‘a comparison of bats and rodents as reservoirs of zoonotic viruses’ |
title_short | Phylogeny matters: revisiting ‘a comparison of bats and rodents as reservoirs of zoonotic viruses’ |
title_sort | phylogeny matters: revisiting ‘a comparison of bats and rodents as reservoirs of zoonotic viruses’ |
topic | Biology (Whole Organism) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408376/ https://www.ncbi.nlm.nih.gov/pubmed/30891262 http://dx.doi.org/10.1098/rsos.181182 |
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