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Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice
Chromodomain Y (CDY) is one of the candidate genes for male dyszoospermia related to Y chromosome microdeletion (YCM). However, the function of CDY in regulating spermatogenesis has not been completely determined. The mouse Cdyl (CDY-like) gene is the homolog of human CDY. In the present study, we g...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408431/ https://www.ncbi.nlm.nih.gov/pubmed/30850578 http://dx.doi.org/10.1038/s41419-019-1455-y |
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author | Xia, Xiaoyu Zhou, Xiaowei Quan, Yanmei Hu, Yanqin Xing, Fengying Li, Zhengzheng Xu, Bufang Xu, Chen Zhang, Aijun |
author_facet | Xia, Xiaoyu Zhou, Xiaowei Quan, Yanmei Hu, Yanqin Xing, Fengying Li, Zhengzheng Xu, Bufang Xu, Chen Zhang, Aijun |
author_sort | Xia, Xiaoyu |
collection | PubMed |
description | Chromodomain Y (CDY) is one of the candidate genes for male dyszoospermia related to Y chromosome microdeletion (YCM). However, the function of CDY in regulating spermatogenesis has not been completely determined. The mouse Cdyl (CDY-like) gene is the homolog of human CDY. In the present study, we generated a germline conditional knockout (cKO) model of mouse Cdyl. Significantly, the Cdyl(cKO) male mice suffered from the defects in spermatogonia maintenance and spermatozoon morphogenesis, demonstrating teratozoospermia and a progressive infertility phenotype in early adulthood. Importantly, patterns of specific histone methylation and acetylation were extensively changed, which disturbed the transcriptome in Cdyl(cKO) testis. Our findings indicated that Cdyl is crucial for spermatogenesis and male fertility, which provides novel insights into the function of CDY gene, as well as the pathogenesis of YCM-related reproductive failure. |
format | Online Article Text |
id | pubmed-6408431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64084312019-03-11 Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice Xia, Xiaoyu Zhou, Xiaowei Quan, Yanmei Hu, Yanqin Xing, Fengying Li, Zhengzheng Xu, Bufang Xu, Chen Zhang, Aijun Cell Death Dis Article Chromodomain Y (CDY) is one of the candidate genes for male dyszoospermia related to Y chromosome microdeletion (YCM). However, the function of CDY in regulating spermatogenesis has not been completely determined. The mouse Cdyl (CDY-like) gene is the homolog of human CDY. In the present study, we generated a germline conditional knockout (cKO) model of mouse Cdyl. Significantly, the Cdyl(cKO) male mice suffered from the defects in spermatogonia maintenance and spermatozoon morphogenesis, demonstrating teratozoospermia and a progressive infertility phenotype in early adulthood. Importantly, patterns of specific histone methylation and acetylation were extensively changed, which disturbed the transcriptome in Cdyl(cKO) testis. Our findings indicated that Cdyl is crucial for spermatogenesis and male fertility, which provides novel insights into the function of CDY gene, as well as the pathogenesis of YCM-related reproductive failure. Nature Publishing Group UK 2019-03-08 /pmc/articles/PMC6408431/ /pubmed/30850578 http://dx.doi.org/10.1038/s41419-019-1455-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Xia, Xiaoyu Zhou, Xiaowei Quan, Yanmei Hu, Yanqin Xing, Fengying Li, Zhengzheng Xu, Bufang Xu, Chen Zhang, Aijun Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice |
title | Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice |
title_full | Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice |
title_fullStr | Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice |
title_full_unstemmed | Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice |
title_short | Germline deletion of Cdyl causes teratozoospermia and progressive infertility in male mice |
title_sort | germline deletion of cdyl causes teratozoospermia and progressive infertility in male mice |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408431/ https://www.ncbi.nlm.nih.gov/pubmed/30850578 http://dx.doi.org/10.1038/s41419-019-1455-y |
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