Targeting of dermal myofibroblasts through death receptor 5 arrests fibrosis in mouse models of scleroderma

Scleroderma is an autoimmune rheumatic disorder accompanied by severe fibrosis in skin and other internal organs. During scleroderma progression, resident fibroblasts undergo activation and convert to α-smooth muscle actin (α-SMA) expressing myofibroblasts (MFBs) with increased capacity to synthesiz...

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Detalles Bibliográficos
Autores principales: Park, Jong-Sung, Oh, Yumin, Park, Yong Joo, Park, Ogyi, Yang, Hoseong, Slania, Stephanie, Hummers, Laura K., Shah, Ami A., An, Hyoung-Tae, Jang, Jiyeon, Horton, Maureen R., Shin, Joseph, Dietz, Harry C., Song, Eric, Na, Dong Hee, Park, Eun Ji, Kim, Kwangmeyung, Lee, Kang Choon, Roschke, Viktor V., Hanes, Justin, Pomper, Martin G., Lee, Seulki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408468/
https://www.ncbi.nlm.nih.gov/pubmed/30850660
http://dx.doi.org/10.1038/s41467-019-09101-4

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