Inhibition of PINK1/Parkin-dependent mitophagy sensitizes multidrug-resistant cancer cells to B5G1, a new betulinic acid analog

Betulinic acid (BA) and its derivatives are a class of high-profile drug candidates, but their anticancer effects on resistant cancer have rarely been reported. Although a few studies indicated mitophagy is related with drug resistance, its role in different cancer types and anticancer agents treatm...

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Detalles Bibliográficos
Autores principales: Yao, Nan, Wang, Chenran, Hu, Nan, Li, Yingjie, Liu, Mingqun, Lei, Yuhe, Chen, Minfeng, Chen, Liping, Chen, Chen, Lan, Ping, Chen, Weimin, Chen, Zhesheng, Fu, Dengrui, Ye, Wencai, Zhang, Dongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408511/
https://www.ncbi.nlm.nih.gov/pubmed/30850585
http://dx.doi.org/10.1038/s41419-019-1470-z

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