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Diversifying the structure of zinc finger nucleases for high-precision genome editing

Genome editing for therapeutic applications often requires cleavage within a narrow sequence window. Here, to enable such high-precision targeting with zinc-finger nucleases (ZFNs), we have developed an expanded set of architectures that collectively increase the configurational options available fo...

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Detalles Bibliográficos
Autores principales:	Paschon, David E., Lussier, Stephanie, Wangzor, Tenzin, Xia, Danny F., Li, Patrick W., Hinkley, Sarah J., Scarlott, Nicholas A., Lam, Stephen C., Waite, Adam J., Truong, Lynn N., Gandhi, Nimisha, Kadam, Bhakti N., Patil, Deepak P., Shivak, David A., Lee, Gary K., Holmes, Michael C., Zhang, Lei, Miller, Jeffrey C., Rebar, Edward J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408524/ https://www.ncbi.nlm.nih.gov/pubmed/30850604 http://dx.doi.org/10.1038/s41467-019-08867-x

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