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The relevance of Brownian relaxation as power absorption mechanism in Magnetic Hyperthermia
The Linear Response Theory (LRT) is a widely accepted framework to analyze the power absorption of magnetic nanoparticles for magnetic fluid hyperthermia. Its validity is restricted to low applied fields and/or to highly anisotropic magnetic nanoparticles. Here, we present a systematic experimental...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408542/ https://www.ncbi.nlm.nih.gov/pubmed/30850704 http://dx.doi.org/10.1038/s41598-019-40341-y |
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author | Torres, Teobaldo E. Lima, Enio Calatayud, M. Pilar Sanz, Beatriz Ibarra, Alfonso Fernández-Pacheco, Rodrigo Mayoral, Alvaro Marquina, Clara Ibarra, M. Ricardo Goya, Gerardo F. |
author_facet | Torres, Teobaldo E. Lima, Enio Calatayud, M. Pilar Sanz, Beatriz Ibarra, Alfonso Fernández-Pacheco, Rodrigo Mayoral, Alvaro Marquina, Clara Ibarra, M. Ricardo Goya, Gerardo F. |
author_sort | Torres, Teobaldo E. |
collection | PubMed |
description | The Linear Response Theory (LRT) is a widely accepted framework to analyze the power absorption of magnetic nanoparticles for magnetic fluid hyperthermia. Its validity is restricted to low applied fields and/or to highly anisotropic magnetic nanoparticles. Here, we present a systematic experimental analysis and numerical calculations of the specific power absorption for highly anisotropic cobalt ferrite (CoFe(2)O(4)) magnetic nanoparticles with different average sizes and in different viscous media. The predominance of Brownian relaxation as the origin of the magnetic losses in these particles is established, and the changes of the Specific Power Absorption (SPA) with the viscosity of the carrier liquid are consistent with the LRT approximation. The impact of viscosity on SPA is relevant for the design of MNPs to heat the intracellular medium during in vitro and in vivo experiments. The combined numerical and experimental analyses presented here shed light on the underlying mechanisms that make highly anisotropic MNPs unsuitable for magnetic hyperthermia. |
format | Online Article Text |
id | pubmed-6408542 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-64085422019-03-12 The relevance of Brownian relaxation as power absorption mechanism in Magnetic Hyperthermia Torres, Teobaldo E. Lima, Enio Calatayud, M. Pilar Sanz, Beatriz Ibarra, Alfonso Fernández-Pacheco, Rodrigo Mayoral, Alvaro Marquina, Clara Ibarra, M. Ricardo Goya, Gerardo F. Sci Rep Article The Linear Response Theory (LRT) is a widely accepted framework to analyze the power absorption of magnetic nanoparticles for magnetic fluid hyperthermia. Its validity is restricted to low applied fields and/or to highly anisotropic magnetic nanoparticles. Here, we present a systematic experimental analysis and numerical calculations of the specific power absorption for highly anisotropic cobalt ferrite (CoFe(2)O(4)) magnetic nanoparticles with different average sizes and in different viscous media. The predominance of Brownian relaxation as the origin of the magnetic losses in these particles is established, and the changes of the Specific Power Absorption (SPA) with the viscosity of the carrier liquid are consistent with the LRT approximation. The impact of viscosity on SPA is relevant for the design of MNPs to heat the intracellular medium during in vitro and in vivo experiments. The combined numerical and experimental analyses presented here shed light on the underlying mechanisms that make highly anisotropic MNPs unsuitable for magnetic hyperthermia. Nature Publishing Group UK 2019-03-08 /pmc/articles/PMC6408542/ /pubmed/30850704 http://dx.doi.org/10.1038/s41598-019-40341-y Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Torres, Teobaldo E. Lima, Enio Calatayud, M. Pilar Sanz, Beatriz Ibarra, Alfonso Fernández-Pacheco, Rodrigo Mayoral, Alvaro Marquina, Clara Ibarra, M. Ricardo Goya, Gerardo F. The relevance of Brownian relaxation as power absorption mechanism in Magnetic Hyperthermia |
title | The relevance of Brownian relaxation as power absorption mechanism in Magnetic Hyperthermia |
title_full | The relevance of Brownian relaxation as power absorption mechanism in Magnetic Hyperthermia |
title_fullStr | The relevance of Brownian relaxation as power absorption mechanism in Magnetic Hyperthermia |
title_full_unstemmed | The relevance of Brownian relaxation as power absorption mechanism in Magnetic Hyperthermia |
title_short | The relevance of Brownian relaxation as power absorption mechanism in Magnetic Hyperthermia |
title_sort | relevance of brownian relaxation as power absorption mechanism in magnetic hyperthermia |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408542/ https://www.ncbi.nlm.nih.gov/pubmed/30850704 http://dx.doi.org/10.1038/s41598-019-40341-y |
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