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Lifespan Changes of the Human Brain In Alzheimer’s Disease

Brain imaging studies have shown that slow and progressive cerebral atrophy characterized the development of Alzheimer’s Disease (AD). Despite a large number of studies dedicated to AD, key questions about the lifespan evolution of AD biomarkers remain open. When does the AD model diverge from the n...

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Autores principales: Coupé, Pierrick, Manjón, José Vicente, Lanuza, Enrique, Catheline, Gwenaelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408544/
https://www.ncbi.nlm.nih.gov/pubmed/30850617
http://dx.doi.org/10.1038/s41598-019-39809-8
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author Coupé, Pierrick
Manjón, José Vicente
Lanuza, Enrique
Catheline, Gwenaelle
author_facet Coupé, Pierrick
Manjón, José Vicente
Lanuza, Enrique
Catheline, Gwenaelle
author_sort Coupé, Pierrick
collection PubMed
description Brain imaging studies have shown that slow and progressive cerebral atrophy characterized the development of Alzheimer’s Disease (AD). Despite a large number of studies dedicated to AD, key questions about the lifespan evolution of AD biomarkers remain open. When does the AD model diverge from the normal aging model? What is the lifespan trajectory of imaging biomarkers for AD? How do the trajectories of biomarkers in AD differ from normal aging? To answer these questions, we proposed an innovative way by inferring brain structure model across the entire lifespan using a massive number of MRI (N = 4329). We compared the normal model based on 2944 control subjects with the pathological model based on 3262 patients (AD + Mild cognitive Impaired subjects) older than 55 years and controls younger than 55 years. Our study provides evidences of early divergence of the AD models from the normal aging trajectory before 40 years for the hippocampus, followed by the lateral ventricles and the amygdala around 40 years. Moreover, our lifespan model reveals the evolution of these biomarkers and suggests close abnormality evolution for the hippocampus and the amygdala, whereas trajectory of ventricular enlargement appears to follow an inverted U-shape. Finally, our models indicate that medial temporal lobe atrophy and ventricular enlargement are two mid-life physiopathological events characterizing AD brain.
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spelling pubmed-64085442019-03-12 Lifespan Changes of the Human Brain In Alzheimer’s Disease Coupé, Pierrick Manjón, José Vicente Lanuza, Enrique Catheline, Gwenaelle Sci Rep Article Brain imaging studies have shown that slow and progressive cerebral atrophy characterized the development of Alzheimer’s Disease (AD). Despite a large number of studies dedicated to AD, key questions about the lifespan evolution of AD biomarkers remain open. When does the AD model diverge from the normal aging model? What is the lifespan trajectory of imaging biomarkers for AD? How do the trajectories of biomarkers in AD differ from normal aging? To answer these questions, we proposed an innovative way by inferring brain structure model across the entire lifespan using a massive number of MRI (N = 4329). We compared the normal model based on 2944 control subjects with the pathological model based on 3262 patients (AD + Mild cognitive Impaired subjects) older than 55 years and controls younger than 55 years. Our study provides evidences of early divergence of the AD models from the normal aging trajectory before 40 years for the hippocampus, followed by the lateral ventricles and the amygdala around 40 years. Moreover, our lifespan model reveals the evolution of these biomarkers and suggests close abnormality evolution for the hippocampus and the amygdala, whereas trajectory of ventricular enlargement appears to follow an inverted U-shape. Finally, our models indicate that medial temporal lobe atrophy and ventricular enlargement are two mid-life physiopathological events characterizing AD brain. Nature Publishing Group UK 2019-03-08 /pmc/articles/PMC6408544/ /pubmed/30850617 http://dx.doi.org/10.1038/s41598-019-39809-8 Text en © The Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Coupé, Pierrick
Manjón, José Vicente
Lanuza, Enrique
Catheline, Gwenaelle
Lifespan Changes of the Human Brain In Alzheimer’s Disease
title Lifespan Changes of the Human Brain In Alzheimer’s Disease
title_full Lifespan Changes of the Human Brain In Alzheimer’s Disease
title_fullStr Lifespan Changes of the Human Brain In Alzheimer’s Disease
title_full_unstemmed Lifespan Changes of the Human Brain In Alzheimer’s Disease
title_short Lifespan Changes of the Human Brain In Alzheimer’s Disease
title_sort lifespan changes of the human brain in alzheimer’s disease
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408544/
https://www.ncbi.nlm.nih.gov/pubmed/30850617
http://dx.doi.org/10.1038/s41598-019-39809-8
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