CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1

The inv(16) acute myeloid leukemia-associated CBFβ-MYH11 fusion is proposed to block normal myeloid differentiation, but whether this subtype of leukemia cells is poised for a unique cell lineage remains unclear. Here, we surveyed the functional consequences of CBFβ-MYH11 in primary inv(16) patient...

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Detalles Bibliográficos
Autores principales: Yi, Guoqiang, Mandoli, Amit, Jussen, Laura, Tijchon, Esther, van Bergen, Maaike G. J. M., Cordonnier, Gaëlle, Hansen, Marten, Kim, Bowon, Nguyen, Luan N., Jansen, Pascal W. T. C., Vermeulen, Michiel, van der Reijden, Bert, van den Akker, Emile, Bond, Jonathan, Martens, Joost H. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408575/
https://www.ncbi.nlm.nih.gov/pubmed/30850577
http://dx.doi.org/10.1038/s41408-019-0194-8

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