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Prenatal treatment with EGCG enriched green tea extract rescues GAD67 related developmental and cognitive defects in Down syndrome mouse models

Down syndrome is a common genetic disorder caused by trisomy of chromosome 21. Brain development in affected foetuses might be improved through prenatal treatment. One potential target is DYRK1A, a multifunctional kinase encoded by chromosome 21 that, when overexpressed, alters neuronal excitation–i...

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Detalles Bibliográficos
Autores principales:	Souchet, Benoit, Duchon, Arnaud, Gu, Yuchen, Dairou, Julien, Chevalier, Claire, Daubigney, Fabrice, Nalesso, Valérie, Créau, Nicole, Yu, Yuejin, Janel, Nathalie, Herault, Yann, Delabar, Jean Maurice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408590/ https://www.ncbi.nlm.nih.gov/pubmed/30850713 http://dx.doi.org/10.1038/s41598-019-40328-9

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