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Comprehensive Genomic Analysis Reveals that the Pioneering Function of FOXA1 Is Independent of Hormonal Signaling

Considerable work has linked hormone receptors, such as estrogen receptor-alpha (ER), with the pioneer factor FOXA1. Altered FOXA1 levels contribute to endocrine-resistant breast cancer, where it maintains ER-chromatin interactions, even in contexts in which cells are refractory to ER-targeted drugs...

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Detalles Bibliográficos
Autores principales:	Glont, Silvia-E., Chernukhin, Igor, Carroll, Jason S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408623/ https://www.ncbi.nlm.nih.gov/pubmed/30840881 http://dx.doi.org/10.1016/j.celrep.2019.02.036

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