Cargando…
Effects of lymph node metastasis of thoracic esophageal squamous cell carcinoma on design of radiotherapy target volume
OBJECTIVE: To analyze the correlation between lymph node metastasis of thoracic esophageal squamous cell carcinoma (ESCC) and clinical and pathological factors, and to provide a reference for the outline of clinical target volume. METHODS: The pathological characteristics of 1034 thoracic ESCC patie...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Professional Medical Publications
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408628/ https://www.ncbi.nlm.nih.gov/pubmed/30881419 http://dx.doi.org/10.12669/pjms.35.1.431 |
_version_ | 1783401804724174848 |
---|---|
author | Pan, Guobing Pan, Haitao Zhang, Yuang Shuai, Haitao |
author_facet | Pan, Guobing Pan, Haitao Zhang, Yuang Shuai, Haitao |
author_sort | Pan, Guobing |
collection | PubMed |
description | OBJECTIVE: To analyze the correlation between lymph node metastasis of thoracic esophageal squamous cell carcinoma (ESCC) and clinical and pathological factors, and to provide a reference for the outline of clinical target volume. METHODS: The pathological characteristics of 1034 thoracic ESCC patients after surgery were described, and the correlations between clinical and pathological factors and lymph node metastasis were studied by univariate and Logistic multivariate analyses. RESULTS: Lymph node metastasis was significantly correlated with tumor length, invasion depth and differentiation degree (P<0.01), but not gender, age, tumor site or pathological type (P>0.05). Logistic multivariate analysis showed that tumor length, invasion depth and differentiation degree were independent risk factors for thoracic ESCC. The lymph node metastasis rates of mid-thoracic ESCC in the middle mediastinum, lower-thoracic ESCC in the lower mediastinum and abdominal cavity were 18.5%, 35.3% and 19.7% respectively in the T1-T2 stage. In the T3-T4 stage, the lymph node metastasis rates of mid-thoracic ESCC in the middle mediastinum and abdominal cavity were 39.6% and 17.4% respectively, and those of lower-thoracic ESCC in middle and lower mediastina and abdominal cavity were 21.1%, 43.4% and 29.8% respectively. Highly/moderately differentiated mid-thoracic ESCC in the middle mediastinum, lower-thoracic ESCC in middle and lower mediastina and abdominal cavity had the lymph node metastasis rates of 34.7%, 15.1%, 33.5% and 23.7% respectively. Lowly differentiated mid-thoracic ESCC in the middle mediastinum and abdominal cavity had the lymph node metastasis rates of 46.9% a 29.6% respectively, and those of lower-thoracic ESCC in middle and lower mediastina and abdominal cavity were 25.5%, 49.1% and 27.3% respectively. CONCLUSION: During the outline of radiotherapy target volume for thoracic ESCC, tumor length, invasion depth and differentiation degree should be comprehensively considered to selectively irradiate the regions prone to lymph node metastasis. |
format | Online Article Text |
id | pubmed-6408628 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Professional Medical Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-64086282019-03-15 Effects of lymph node metastasis of thoracic esophageal squamous cell carcinoma on design of radiotherapy target volume Pan, Guobing Pan, Haitao Zhang, Yuang Shuai, Haitao Pak J Med Sci Original Article OBJECTIVE: To analyze the correlation between lymph node metastasis of thoracic esophageal squamous cell carcinoma (ESCC) and clinical and pathological factors, and to provide a reference for the outline of clinical target volume. METHODS: The pathological characteristics of 1034 thoracic ESCC patients after surgery were described, and the correlations between clinical and pathological factors and lymph node metastasis were studied by univariate and Logistic multivariate analyses. RESULTS: Lymph node metastasis was significantly correlated with tumor length, invasion depth and differentiation degree (P<0.01), but not gender, age, tumor site or pathological type (P>0.05). Logistic multivariate analysis showed that tumor length, invasion depth and differentiation degree were independent risk factors for thoracic ESCC. The lymph node metastasis rates of mid-thoracic ESCC in the middle mediastinum, lower-thoracic ESCC in the lower mediastinum and abdominal cavity were 18.5%, 35.3% and 19.7% respectively in the T1-T2 stage. In the T3-T4 stage, the lymph node metastasis rates of mid-thoracic ESCC in the middle mediastinum and abdominal cavity were 39.6% and 17.4% respectively, and those of lower-thoracic ESCC in middle and lower mediastina and abdominal cavity were 21.1%, 43.4% and 29.8% respectively. Highly/moderately differentiated mid-thoracic ESCC in the middle mediastinum, lower-thoracic ESCC in middle and lower mediastina and abdominal cavity had the lymph node metastasis rates of 34.7%, 15.1%, 33.5% and 23.7% respectively. Lowly differentiated mid-thoracic ESCC in the middle mediastinum and abdominal cavity had the lymph node metastasis rates of 46.9% a 29.6% respectively, and those of lower-thoracic ESCC in middle and lower mediastina and abdominal cavity were 25.5%, 49.1% and 27.3% respectively. CONCLUSION: During the outline of radiotherapy target volume for thoracic ESCC, tumor length, invasion depth and differentiation degree should be comprehensively considered to selectively irradiate the regions prone to lymph node metastasis. Professional Medical Publications 2019 /pmc/articles/PMC6408628/ /pubmed/30881419 http://dx.doi.org/10.12669/pjms.35.1.431 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Pan, Guobing Pan, Haitao Zhang, Yuang Shuai, Haitao Effects of lymph node metastasis of thoracic esophageal squamous cell carcinoma on design of radiotherapy target volume |
title | Effects of lymph node metastasis of thoracic esophageal squamous cell carcinoma on design of radiotherapy target volume |
title_full | Effects of lymph node metastasis of thoracic esophageal squamous cell carcinoma on design of radiotherapy target volume |
title_fullStr | Effects of lymph node metastasis of thoracic esophageal squamous cell carcinoma on design of radiotherapy target volume |
title_full_unstemmed | Effects of lymph node metastasis of thoracic esophageal squamous cell carcinoma on design of radiotherapy target volume |
title_short | Effects of lymph node metastasis of thoracic esophageal squamous cell carcinoma on design of radiotherapy target volume |
title_sort | effects of lymph node metastasis of thoracic esophageal squamous cell carcinoma on design of radiotherapy target volume |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408628/ https://www.ncbi.nlm.nih.gov/pubmed/30881419 http://dx.doi.org/10.12669/pjms.35.1.431 |
work_keys_str_mv | AT panguobing effectsoflymphnodemetastasisofthoracicesophagealsquamouscellcarcinomaondesignofradiotherapytargetvolume AT panhaitao effectsoflymphnodemetastasisofthoracicesophagealsquamouscellcarcinomaondesignofradiotherapytargetvolume AT zhangyuang effectsoflymphnodemetastasisofthoracicesophagealsquamouscellcarcinomaondesignofradiotherapytargetvolume AT shuaihaitao effectsoflymphnodemetastasisofthoracicesophagealsquamouscellcarcinomaondesignofradiotherapytargetvolume |