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The role of Endocan as a Prognostic Biomarker in community-acquired pneumonia

OBJECTIVE: The aim of this study was to determine the importance of using endocan as a biomarker in deciding the setting of treatment and predicting prognosis in patients with community-acquired pneumonia (CAP). METHODS: This prospective, case-control study was conducted at Okmeydani Training and Re...

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Autores principales: Gunaydin, Senay, Kucuk, Mehmet, Gunaydin, Ulug Mutlu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Professional Medical Publications 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408646/
https://www.ncbi.nlm.nih.gov/pubmed/30881408
http://dx.doi.org/10.12669/pjms.35.1.280
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author Gunaydin, Senay
Kucuk, Mehmet
Gunaydin, Ulug Mutlu
author_facet Gunaydin, Senay
Kucuk, Mehmet
Gunaydin, Ulug Mutlu
author_sort Gunaydin, Senay
collection PubMed
description OBJECTIVE: The aim of this study was to determine the importance of using endocan as a biomarker in deciding the setting of treatment and predicting prognosis in patients with community-acquired pneumonia (CAP). METHODS: This prospective, case-control study was conducted at Okmeydani Training and Research Hospital between November 20, 2016 to March 20(th) 2017. Blood samples were obtained from 63 patients who were admitted to internal medicine clinic due to CAP and 25 volunteers without active infection. Serum samples were centrifuged at 1000G for 15 minutes and stored at -20ºC. Samples were analyzed using human ESM1 (endocan) (Lot No: AK0017MAR0830) (Elabscience, Texas, USA) kit with Robonik (Mumbai, India) ELISA Plate Reader and Washer. Demographic and clinical data of the patients were recorded. CURB-65, qSOFA and Pneumonia Severity Index (PSI) scores were calculated. Primary endpoint of the study was 30-days mortality. RESULTS: Mean serum endocan levels of the study group and the control group were 30.99±3.3 pg/ml and 246.5±49.95pg/ml, respectively. The difference between groups was statistically significant (p<0.005). 30-days mortality rate was 12.7% with eight patients, three of which died subsequently in the ICU. When patients were classified according to PSI and CURB-65 scores, endocan levels of PSI class ≥4 and CURB-65 ≥2 individuals were found to be significantly different than the control group. ROC analysis showed that serum endocan levels less than 64.96pg/ml has 85.2% sensitivity and 83.3% specificity for PSI class ≥4 and 82.4% sensitivity and 55.6% specificity for CURB-65 score ≥2. CONCLUSION: Serum endocan levels are significantly lower in patients with community-acquired pneumonia than the control group.
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spelling pubmed-64086462019-03-15 The role of Endocan as a Prognostic Biomarker in community-acquired pneumonia Gunaydin, Senay Kucuk, Mehmet Gunaydin, Ulug Mutlu Pak J Med Sci Original Article OBJECTIVE: The aim of this study was to determine the importance of using endocan as a biomarker in deciding the setting of treatment and predicting prognosis in patients with community-acquired pneumonia (CAP). METHODS: This prospective, case-control study was conducted at Okmeydani Training and Research Hospital between November 20, 2016 to March 20(th) 2017. Blood samples were obtained from 63 patients who were admitted to internal medicine clinic due to CAP and 25 volunteers without active infection. Serum samples were centrifuged at 1000G for 15 minutes and stored at -20ºC. Samples were analyzed using human ESM1 (endocan) (Lot No: AK0017MAR0830) (Elabscience, Texas, USA) kit with Robonik (Mumbai, India) ELISA Plate Reader and Washer. Demographic and clinical data of the patients were recorded. CURB-65, qSOFA and Pneumonia Severity Index (PSI) scores were calculated. Primary endpoint of the study was 30-days mortality. RESULTS: Mean serum endocan levels of the study group and the control group were 30.99±3.3 pg/ml and 246.5±49.95pg/ml, respectively. The difference between groups was statistically significant (p<0.005). 30-days mortality rate was 12.7% with eight patients, three of which died subsequently in the ICU. When patients were classified according to PSI and CURB-65 scores, endocan levels of PSI class ≥4 and CURB-65 ≥2 individuals were found to be significantly different than the control group. ROC analysis showed that serum endocan levels less than 64.96pg/ml has 85.2% sensitivity and 83.3% specificity for PSI class ≥4 and 82.4% sensitivity and 55.6% specificity for CURB-65 score ≥2. CONCLUSION: Serum endocan levels are significantly lower in patients with community-acquired pneumonia than the control group. Professional Medical Publications 2019 /pmc/articles/PMC6408646/ /pubmed/30881408 http://dx.doi.org/10.12669/pjms.35.1.280 Text en Copyright: © Pakistan Journal of Medical Sciences http://creativecommons.org/licenses/by/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Gunaydin, Senay
Kucuk, Mehmet
Gunaydin, Ulug Mutlu
The role of Endocan as a Prognostic Biomarker in community-acquired pneumonia
title The role of Endocan as a Prognostic Biomarker in community-acquired pneumonia
title_full The role of Endocan as a Prognostic Biomarker in community-acquired pneumonia
title_fullStr The role of Endocan as a Prognostic Biomarker in community-acquired pneumonia
title_full_unstemmed The role of Endocan as a Prognostic Biomarker in community-acquired pneumonia
title_short The role of Endocan as a Prognostic Biomarker in community-acquired pneumonia
title_sort role of endocan as a prognostic biomarker in community-acquired pneumonia
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408646/
https://www.ncbi.nlm.nih.gov/pubmed/30881408
http://dx.doi.org/10.12669/pjms.35.1.280
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