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Orbital Radiotherapy Plus Concomitant Steroids in Moderate-to-Severe Graves’ Ophthalmopathy: Good Results After Long-Term Follow-Up
BACKGROUND: Orbital radiotherapy (RT) is an effective and consolidate treatment for steroid-refractory Graves’ ophthalmopathy (GO); however, long term effects are not well known. OBJECTIVES: The aim of this study was to evaluate the long term efficacy and toxicity of orbital RT plus concomitant syst...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Kowsar
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408739/ https://www.ncbi.nlm.nih.gov/pubmed/30881470 http://dx.doi.org/10.5812/ijem.84427 |
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author | Nicosia, Luca Reverberi, Chiara Agolli, Linda Marinelli, Luca De Sanctis, Vitaliana Minniti, Giuseppe Valeriani, Maurizio Osti, Mattia F |
author_facet | Nicosia, Luca Reverberi, Chiara Agolli, Linda Marinelli, Luca De Sanctis, Vitaliana Minniti, Giuseppe Valeriani, Maurizio Osti, Mattia F |
author_sort | Nicosia, Luca |
collection | PubMed |
description | BACKGROUND: Orbital radiotherapy (RT) is an effective and consolidate treatment for steroid-refractory Graves’ ophthalmopathy (GO); however, long term effects are not well known. OBJECTIVES: The aim of this study was to evaluate the long term efficacy and toxicity of orbital RT plus concomitant systemic steroids in a population of patients with moderate-to-severe GO or with eyesight threatening symptoms refractory to steroids. METHODS: Forty patients with moderate-to-severe GO or with eyesight threatening symptoms not responsive/resistant to steroids were treated with orbital RT at the dose of 20 Gy in 10 fractions plus concomitant steroids. Clinical activity score (CAS) and symptoms status were evaluated to determine response to the treatment. RESULTS: We reported overall improvement of symptoms, in particular, a regression at 1-year of diplopia in 32.5% eye movement impairment in 42.5%, eyesight in 27.5% and a 2 point reduction in CAS. After a median time of 56 months 21.9% of the patients underwent orbital decompression for relapse of GO, 4.8% received surgical correction of strabismus, and 2.4% received eyelid lipectomy. Acute toxicity was mild; grade 1 - 2 keratitis occurred in 19.5% of the patients and grade 3 keratitis was observed in 2.4% of the patients. Cataract occurred in 7.4% of the patients after a median time of 24-month-follow-up. No secondary malignancies were reported. CONCLUSIONS: Our results reported the long-term efficacy and the good tolerance of orbital RT. The combination of RT plus steroids in this setting may avoid or delay performing the surgery in some cases. |
format | Online Article Text |
id | pubmed-6408739 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Kowsar |
record_format | MEDLINE/PubMed |
spelling | pubmed-64087392019-03-16 Orbital Radiotherapy Plus Concomitant Steroids in Moderate-to-Severe Graves’ Ophthalmopathy: Good Results After Long-Term Follow-Up Nicosia, Luca Reverberi, Chiara Agolli, Linda Marinelli, Luca De Sanctis, Vitaliana Minniti, Giuseppe Valeriani, Maurizio Osti, Mattia F Int J Endocrinol Metab Research Article BACKGROUND: Orbital radiotherapy (RT) is an effective and consolidate treatment for steroid-refractory Graves’ ophthalmopathy (GO); however, long term effects are not well known. OBJECTIVES: The aim of this study was to evaluate the long term efficacy and toxicity of orbital RT plus concomitant systemic steroids in a population of patients with moderate-to-severe GO or with eyesight threatening symptoms refractory to steroids. METHODS: Forty patients with moderate-to-severe GO or with eyesight threatening symptoms not responsive/resistant to steroids were treated with orbital RT at the dose of 20 Gy in 10 fractions plus concomitant steroids. Clinical activity score (CAS) and symptoms status were evaluated to determine response to the treatment. RESULTS: We reported overall improvement of symptoms, in particular, a regression at 1-year of diplopia in 32.5% eye movement impairment in 42.5%, eyesight in 27.5% and a 2 point reduction in CAS. After a median time of 56 months 21.9% of the patients underwent orbital decompression for relapse of GO, 4.8% received surgical correction of strabismus, and 2.4% received eyelid lipectomy. Acute toxicity was mild; grade 1 - 2 keratitis occurred in 19.5% of the patients and grade 3 keratitis was observed in 2.4% of the patients. Cataract occurred in 7.4% of the patients after a median time of 24-month-follow-up. No secondary malignancies were reported. CONCLUSIONS: Our results reported the long-term efficacy and the good tolerance of orbital RT. The combination of RT plus steroids in this setting may avoid or delay performing the surgery in some cases. Kowsar 2019-01-27 /pmc/articles/PMC6408739/ /pubmed/30881470 http://dx.doi.org/10.5812/ijem.84427 Text en Copyright © 2019, International Journal of Endocrinology and Metabolism http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/) which permits copy and redistribute the material just in noncommercial usages, provided the original work is properly cited. |
spellingShingle | Research Article Nicosia, Luca Reverberi, Chiara Agolli, Linda Marinelli, Luca De Sanctis, Vitaliana Minniti, Giuseppe Valeriani, Maurizio Osti, Mattia F Orbital Radiotherapy Plus Concomitant Steroids in Moderate-to-Severe Graves’ Ophthalmopathy: Good Results After Long-Term Follow-Up |
title | Orbital Radiotherapy Plus Concomitant Steroids in Moderate-to-Severe Graves’ Ophthalmopathy: Good Results After Long-Term Follow-Up |
title_full | Orbital Radiotherapy Plus Concomitant Steroids in Moderate-to-Severe Graves’ Ophthalmopathy: Good Results After Long-Term Follow-Up |
title_fullStr | Orbital Radiotherapy Plus Concomitant Steroids in Moderate-to-Severe Graves’ Ophthalmopathy: Good Results After Long-Term Follow-Up |
title_full_unstemmed | Orbital Radiotherapy Plus Concomitant Steroids in Moderate-to-Severe Graves’ Ophthalmopathy: Good Results After Long-Term Follow-Up |
title_short | Orbital Radiotherapy Plus Concomitant Steroids in Moderate-to-Severe Graves’ Ophthalmopathy: Good Results After Long-Term Follow-Up |
title_sort | orbital radiotherapy plus concomitant steroids in moderate-to-severe graves’ ophthalmopathy: good results after long-term follow-up |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408739/ https://www.ncbi.nlm.nih.gov/pubmed/30881470 http://dx.doi.org/10.5812/ijem.84427 |
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