TFE3 fusions escape from controlling of mTOR signaling pathway and accumulate in the nucleus promoting genes expression in Xp11.2 translocation renal cell carcinomas

BACKGROUND: Xp11.2 translocation renal cell carcinoma (tRCC) is mainly caused by translocation of the TFE3 gene located on chromosome Xp11.2 and is characterized by overexpression of the TFE3 fusion gene. Patients are diagnosed with tRCC usually before 45 years of age with poor prognosis. We investi...

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Detalles Bibliográficos
Autores principales: Yin, Xiaoqin, Wang, Bo, Gan, Weidong, Zhuang, Wenyuan, Xiang, Zou, Han, Xiaodong, Li, Dongmei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408813/
https://www.ncbi.nlm.nih.gov/pubmed/30849994
http://dx.doi.org/10.1186/s13046-019-1101-7

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