The role of exosomal noncoding RNAs in cancer

Extracellular vesicles (EVs) membranes enclose nanosized vesicles with a size range of 30–150 nm and are plentiful in our body in both physiological and pathological conditions. Exosomes, a type of EV, are important mediators of intracellular communication among tumor cells, immune cells, and stroma...

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Detalles Bibliográficos
Autores principales: Xie, Yan, Dang, Wei, Zhang, Siwei, Yue, Wenxing, Yang, Li, Zhai, Xingyu, Yan, Qijia, Lu, Jianhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408816/
https://www.ncbi.nlm.nih.gov/pubmed/30849983
http://dx.doi.org/10.1186/s12943-019-0984-4
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author Xie, Yan
Dang, Wei
Zhang, Siwei
Yue, Wenxing
Yang, Li
Zhai, Xingyu
Yan, Qijia
Lu, Jianhong
author_facet Xie, Yan
Dang, Wei
Zhang, Siwei
Yue, Wenxing
Yang, Li
Zhai, Xingyu
Yan, Qijia
Lu, Jianhong
author_sort Xie, Yan
collection PubMed
description Extracellular vesicles (EVs) membranes enclose nanosized vesicles with a size range of 30–150 nm and are plentiful in our body in both physiological and pathological conditions. Exosomes, a type of EV, are important mediators of intracellular communication among tumor cells, immune cells, and stromal cells. They can shuttle bioactive molecules, such as proteins, lipids, RNA, and DNA; however, the precise function of EVs remains largely unknown. In recent years, tumor-associated cargo in exosomes has been a hot topic in research, especially with respect to noncoding RNAs (ncRNAs). Herein, we review the role of exosomal ncRNAs, including miRNAs and long noncoding RNAs, in tumor biological processes. Clinically, exosomal ncRNAs may eventually become novel biomarkers and therapeutic targets in cancer progression.
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spelling pubmed-64088162019-03-21 The role of exosomal noncoding RNAs in cancer Xie, Yan Dang, Wei Zhang, Siwei Yue, Wenxing Yang, Li Zhai, Xingyu Yan, Qijia Lu, Jianhong Mol Cancer Review Extracellular vesicles (EVs) membranes enclose nanosized vesicles with a size range of 30–150 nm and are plentiful in our body in both physiological and pathological conditions. Exosomes, a type of EV, are important mediators of intracellular communication among tumor cells, immune cells, and stromal cells. They can shuttle bioactive molecules, such as proteins, lipids, RNA, and DNA; however, the precise function of EVs remains largely unknown. In recent years, tumor-associated cargo in exosomes has been a hot topic in research, especially with respect to noncoding RNAs (ncRNAs). Herein, we review the role of exosomal ncRNAs, including miRNAs and long noncoding RNAs, in tumor biological processes. Clinically, exosomal ncRNAs may eventually become novel biomarkers and therapeutic targets in cancer progression. BioMed Central 2019-03-09 /pmc/articles/PMC6408816/ /pubmed/30849983 http://dx.doi.org/10.1186/s12943-019-0984-4 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Xie, Yan
Dang, Wei
Zhang, Siwei
Yue, Wenxing
Yang, Li
Zhai, Xingyu
Yan, Qijia
Lu, Jianhong
The role of exosomal noncoding RNAs in cancer
title The role of exosomal noncoding RNAs in cancer
title_full The role of exosomal noncoding RNAs in cancer
title_fullStr The role of exosomal noncoding RNAs in cancer
title_full_unstemmed The role of exosomal noncoding RNAs in cancer
title_short The role of exosomal noncoding RNAs in cancer
title_sort role of exosomal noncoding rnas in cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408816/
https://www.ncbi.nlm.nih.gov/pubmed/30849983
http://dx.doi.org/10.1186/s12943-019-0984-4
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