Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD7687 on plasma triacylglycerol

We have developed a novel mechanistic pharmacokinetic‐pharmacodynamic (PK/PD) model to describe the time course of plasma triglyceride (TAG) after Oral Lipid Tolerance Test (OLTT) and the effects of AZD7687, an inhibitor of diacylglycerol acyltransferase 1 (DGAT1), in humans, rats, and mice. Pharmac...

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Detalles Bibliográficos
Autores principales: Morentin Gutierrez, Pablo, Yates, James, Nilsson, Catarina, Birtles, Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408865/
https://www.ncbi.nlm.nih.gov/pubmed/30899516
http://dx.doi.org/10.1002/prp2.465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408865/
https://www.ncbi.nlm.nih.gov/pubmed/30899516
http://dx.doi.org/10.1002/prp2.465

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