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Evolving data analysis of an Oral Lipid Tolerance Test toward the standard for the Oral Glucose Tolerance Test: Cross species modeling effects of AZD7687 on plasma triacylglycerol

We have developed a novel mechanistic pharmacokinetic‐pharmacodynamic (PK/PD) model to describe the time course of plasma triglyceride (TAG) after Oral Lipid Tolerance Test (OLTT) and the effects of AZD7687, an inhibitor of diacylglycerol acyltransferase 1 (DGAT1), in humans, rats, and mice. Pharmac...

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Detalles Bibliográficos
Autores principales:	Morentin Gutierrez, Pablo, Yates, James, Nilsson, Catarina, Birtles, Sue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408865/ https://www.ncbi.nlm.nih.gov/pubmed/30899516 http://dx.doi.org/10.1002/prp2.465

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