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The journey from gene knockout to clinical medicine: telotristat and sotagliflozin
Gene knockout has been a powerful technique to evaluate the physiologic role of selected gene products. Lexicon pioneered high-throughput gene knockout technology and went further in designing agents to inhibit products of gene expression. Two agents have entered late-stage development. Telotristat...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408923/ https://www.ncbi.nlm.nih.gov/pubmed/30880915 http://dx.doi.org/10.2147/DDDT.S144556 |