Netrin Family: Role for Protein Isoforms in Cancer

Netrins form a family of secreted and membrane-associated proteins. Netrins are involved in processes for axonal guidance, morphogenesis, and angiogenesis by regulating cell migration and survival. These processes are of special interest in tumor biology. From the netrin genes various isoforms are t...

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Detalles Bibliográficos
Autores principales: Bruikman, Caroline Suzanne, Zhang, Huayu, Kemper, Anneli Maite, van Gils, Janine Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408995/
https://www.ncbi.nlm.nih.gov/pubmed/30923634
http://dx.doi.org/10.1155/2019/3947123
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author Bruikman, Caroline Suzanne
Zhang, Huayu
Kemper, Anneli Maite
van Gils, Janine Maria
author_facet Bruikman, Caroline Suzanne
Zhang, Huayu
Kemper, Anneli Maite
van Gils, Janine Maria
author_sort Bruikman, Caroline Suzanne
collection PubMed
description Netrins form a family of secreted and membrane-associated proteins. Netrins are involved in processes for axonal guidance, morphogenesis, and angiogenesis by regulating cell migration and survival. These processes are of special interest in tumor biology. From the netrin genes various isoforms are translated and regulated by alternative splicing. We review here the diversity of isoforms of the netrin family members and their known and potential roles in cancer.
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spelling pubmed-64089952019-03-28 Netrin Family: Role for Protein Isoforms in Cancer Bruikman, Caroline Suzanne Zhang, Huayu Kemper, Anneli Maite van Gils, Janine Maria J Nucleic Acids Review Article Netrins form a family of secreted and membrane-associated proteins. Netrins are involved in processes for axonal guidance, morphogenesis, and angiogenesis by regulating cell migration and survival. These processes are of special interest in tumor biology. From the netrin genes various isoforms are translated and regulated by alternative splicing. We review here the diversity of isoforms of the netrin family members and their known and potential roles in cancer. Hindawi 2019-02-24 /pmc/articles/PMC6408995/ /pubmed/30923634 http://dx.doi.org/10.1155/2019/3947123 Text en Copyright © 2019 Caroline Suzanne Bruikman et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bruikman, Caroline Suzanne
Zhang, Huayu
Kemper, Anneli Maite
van Gils, Janine Maria
Netrin Family: Role for Protein Isoforms in Cancer
title Netrin Family: Role for Protein Isoforms in Cancer
title_full Netrin Family: Role for Protein Isoforms in Cancer
title_fullStr Netrin Family: Role for Protein Isoforms in Cancer
title_full_unstemmed Netrin Family: Role for Protein Isoforms in Cancer
title_short Netrin Family: Role for Protein Isoforms in Cancer
title_sort netrin family: role for protein isoforms in cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6408995/
https://www.ncbi.nlm.nih.gov/pubmed/30923634
http://dx.doi.org/10.1155/2019/3947123
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AT vangilsjaninemaria netrinfamilyroleforproteinisoformsincancer

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