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Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells

Low back pain is a major cause of disability worldwide. Although numerous potential biomarkers for the early diagnosis or treatment of intervertebral disc degeneration (IDD) have been identified subsequent to the development of molecular biology technologies, the mechanisms of IDD remain unknown. Pu...

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Autores principales: Xunlu, Yin, Minshan, Feng, Liguo, Zhu, Jiawen, Zhan, Xu, Wei, Jie, Yu, Shangquan, Wang, He, Yin, Long, Liang, Tao, Han, Xuepeng, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409044/
https://www.ncbi.nlm.nih.gov/pubmed/30915367
http://dx.doi.org/10.1155/2019/9890279
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author Xunlu, Yin
Minshan, Feng
Liguo, Zhu
Jiawen, Zhan
Xu, Wei
Jie, Yu
Shangquan, Wang
He, Yin
Long, Liang
Tao, Han
Xuepeng, Li
author_facet Xunlu, Yin
Minshan, Feng
Liguo, Zhu
Jiawen, Zhan
Xu, Wei
Jie, Yu
Shangquan, Wang
He, Yin
Long, Liang
Tao, Han
Xuepeng, Li
author_sort Xunlu, Yin
collection PubMed
description Low back pain is a major cause of disability worldwide. Although numerous potential biomarkers for the early diagnosis or treatment of intervertebral disc degeneration (IDD) have been identified subsequent to the development of molecular biology technologies, the mechanisms of IDD remain unknown. Published studies found the unbalance of anabolism and catabolism of annulus fibrosus (AF) played an important role in it. The present study was aimed to identify the potential targets and signaling pathways of IDD, through the combined analysis of differential expression and based on the Gene Expression Omnibus (GEO) dataset from NCBI. PPI Networks Analysis indicated that MMP2 and AGE-RAGE signaling pathway and estrogen signaling pathway may play important roles in initiation and development of IDD. This study forecasted the pathogenesis molecular mechanism of IDD and the potential prognostic and diagnostic biomarkers, but we need to make further molecular biological experiments to confirm our assumptions.
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spelling pubmed-64090442019-03-26 Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells Xunlu, Yin Minshan, Feng Liguo, Zhu Jiawen, Zhan Xu, Wei Jie, Yu Shangquan, Wang He, Yin Long, Liang Tao, Han Xuepeng, Li Biomed Res Int Research Article Low back pain is a major cause of disability worldwide. Although numerous potential biomarkers for the early diagnosis or treatment of intervertebral disc degeneration (IDD) have been identified subsequent to the development of molecular biology technologies, the mechanisms of IDD remain unknown. Published studies found the unbalance of anabolism and catabolism of annulus fibrosus (AF) played an important role in it. The present study was aimed to identify the potential targets and signaling pathways of IDD, through the combined analysis of differential expression and based on the Gene Expression Omnibus (GEO) dataset from NCBI. PPI Networks Analysis indicated that MMP2 and AGE-RAGE signaling pathway and estrogen signaling pathway may play important roles in initiation and development of IDD. This study forecasted the pathogenesis molecular mechanism of IDD and the potential prognostic and diagnostic biomarkers, but we need to make further molecular biological experiments to confirm our assumptions. Hindawi 2019-02-21 /pmc/articles/PMC6409044/ /pubmed/30915367 http://dx.doi.org/10.1155/2019/9890279 Text en Copyright © 2019 Yin Xunlu et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Xunlu, Yin
Minshan, Feng
Liguo, Zhu
Jiawen, Zhan
Xu, Wei
Jie, Yu
Shangquan, Wang
He, Yin
Long, Liang
Tao, Han
Xuepeng, Li
Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells
title Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells
title_full Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells
title_fullStr Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells
title_full_unstemmed Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells
title_short Integrative Bioinformatics Analysis Reveals Potential Gene Biomarkers and Analysis of Function in Human Degenerative Disc Annulus Fibrosus Cells
title_sort integrative bioinformatics analysis reveals potential gene biomarkers and analysis of function in human degenerative disc annulus fibrosus cells
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409044/
https://www.ncbi.nlm.nih.gov/pubmed/30915367
http://dx.doi.org/10.1155/2019/9890279
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