Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up

In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques...

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Autores principales: Muñoz, Gabriela, Vergara, Camilo, Martínez, Gabriela, Apt, Werner, Zulantay, Inés
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society for Parasitology and Tropical Medicine 2019
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409214/
https://www.ncbi.nlm.nih.gov/pubmed/30840798
http://dx.doi.org/10.3347/kjp.2019.57.1.39
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author Muñoz, Gabriela
Vergara, Camilo
Martínez, Gabriela
Apt, Werner
Zulantay, Inés
author_facet Muñoz, Gabriela
Vergara, Camilo
Martínez, Gabriela
Apt, Werner
Zulantay, Inés
author_sort Muñoz, Gabriela
collection PubMed
description In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques of indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) IgG comparing 2 groups of patients, treated and non treated. Mann-Whitney test was performed for ELISA and IFA, with significant difference between the groups (P<0.05). IgG levels were lower in individuals treated compared with untreated patients, indicating chemotherapeutic efficacy in prolonged follow-up.
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spelling pubmed-64092142019-03-15 Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up Muñoz, Gabriela Vergara, Camilo Martínez, Gabriela Apt, Werner Zulantay, Inés Korean J Parasitol Brief Communication In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques of indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) IgG comparing 2 groups of patients, treated and non treated. Mann-Whitney test was performed for ELISA and IFA, with significant difference between the groups (P<0.05). IgG levels were lower in individuals treated compared with untreated patients, indicating chemotherapeutic efficacy in prolonged follow-up. The Korean Society for Parasitology and Tropical Medicine 2019-02 2019-02-26 /pmc/articles/PMC6409214/ /pubmed/30840798 http://dx.doi.org/10.3347/kjp.2019.57.1.39 Text en Copyright © 2019 by The Korean Society for Parasitology and Tropical Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
Muñoz, Gabriela
Vergara, Camilo
Martínez, Gabriela
Apt, Werner
Zulantay, Inés
Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up
title Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up
title_full Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up
title_fullStr Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up
title_full_unstemmed Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up
title_short Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up
title_sort quantification of immunoglobulin g against trypanosoma cruzi in individuals with chronic chagas disease treated with nifurtimox and evaluated in prolonged follow-up
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409214/
https://www.ncbi.nlm.nih.gov/pubmed/30840798
http://dx.doi.org/10.3347/kjp.2019.57.1.39
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