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Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease

Neutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneo...

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Detalles Bibliográficos
Autores principales: Grieshaber-Bouyer, Ricardo, Nigrovic, Peter A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409342/
https://www.ncbi.nlm.nih.gov/pubmed/30886615
http://dx.doi.org/10.3389/fimmu.2019.00346
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author Grieshaber-Bouyer, Ricardo
Nigrovic, Peter A.
author_facet Grieshaber-Bouyer, Ricardo
Nigrovic, Peter A.
author_sort Grieshaber-Bouyer, Ricardo
collection PubMed
description Neutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneous, offering possibilities for selective intervention. Here we review heterogeneity within the neutrophil population as well as in the pathways mediating neutrophil recruitment to inflamed tissues with a view to outlining opportunities for therapeutic manipulation in inflammatory disease.
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spelling pubmed-64093422019-03-18 Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease Grieshaber-Bouyer, Ricardo Nigrovic, Peter A. Front Immunol Immunology Neutrophils are versatile innate effector cells essential for immune defense but also responsible for pathologic inflammation. This dual role complicates therapeutic targeting. However, neither neutrophils themselves nor the mechanisms they employ in different forms of immune responses are homogeneous, offering possibilities for selective intervention. Here we review heterogeneity within the neutrophil population as well as in the pathways mediating neutrophil recruitment to inflamed tissues with a view to outlining opportunities for therapeutic manipulation in inflammatory disease. Frontiers Media S.A. 2019-03-04 /pmc/articles/PMC6409342/ /pubmed/30886615 http://dx.doi.org/10.3389/fimmu.2019.00346 Text en Copyright © 2019 Grieshaber-Bouyer and Nigrovic. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Grieshaber-Bouyer, Ricardo
Nigrovic, Peter A.
Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease
title Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease
title_full Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease
title_fullStr Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease
title_full_unstemmed Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease
title_short Neutrophil Heterogeneity as Therapeutic Opportunity in Immune-Mediated Disease
title_sort neutrophil heterogeneity as therapeutic opportunity in immune-mediated disease
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409342/
https://www.ncbi.nlm.nih.gov/pubmed/30886615
http://dx.doi.org/10.3389/fimmu.2019.00346
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