Cargando…

Recent Advances for the Direct Introduction of the CF(2)Me Moiety

Fluorine-containing molecules are compounds of interest in materials as well as in pharmaceutical and agrochemical industries. Therefore, developments in that research field are tremendous and a special focus was dedicated to the design and the study of emergent fluorinated groups. In particular, th...

Descripción completa

Detalles Bibliográficos
Autores principales: Carbonnel, Elodie, Poisson, Thomas, Jubault, Philippe, Pannecoucke, Xavier, Besset, Tatiana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409352/
https://www.ncbi.nlm.nih.gov/pubmed/30886846
http://dx.doi.org/10.3389/fchem.2019.00111
_version_ 1783401948213411840
author Carbonnel, Elodie
Poisson, Thomas
Jubault, Philippe
Pannecoucke, Xavier
Besset, Tatiana
author_facet Carbonnel, Elodie
Poisson, Thomas
Jubault, Philippe
Pannecoucke, Xavier
Besset, Tatiana
author_sort Carbonnel, Elodie
collection PubMed
description Fluorine-containing molecules are compounds of interest in materials as well as in pharmaceutical and agrochemical industries. Therefore, developments in that research field are tremendous and a special focus was dedicated to the design and the study of emergent fluorinated groups. In particular, the CF(2)Me residue is attractive as it could be used for example as a bioisostere of the methoxy group. Despite the clear asset that represents this fluorinated moiety and in complement to the traditional approaches used to construct the CF(2)Me residue from existing functional groups, the quest for direct methodologies for the 1,1-difluoroethylation reaction of molecules has triggered a strong interest from the scientific community. This Mini-review will focus on the recent advances toward the design of reagents and their applications for the direct 1,1-difluoroethylation of various classes of compounds.
format Online
Article
Text
id pubmed-6409352
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-64093522019-03-18 Recent Advances for the Direct Introduction of the CF(2)Me Moiety Carbonnel, Elodie Poisson, Thomas Jubault, Philippe Pannecoucke, Xavier Besset, Tatiana Front Chem Chemistry Fluorine-containing molecules are compounds of interest in materials as well as in pharmaceutical and agrochemical industries. Therefore, developments in that research field are tremendous and a special focus was dedicated to the design and the study of emergent fluorinated groups. In particular, the CF(2)Me residue is attractive as it could be used for example as a bioisostere of the methoxy group. Despite the clear asset that represents this fluorinated moiety and in complement to the traditional approaches used to construct the CF(2)Me residue from existing functional groups, the quest for direct methodologies for the 1,1-difluoroethylation reaction of molecules has triggered a strong interest from the scientific community. This Mini-review will focus on the recent advances toward the design of reagents and their applications for the direct 1,1-difluoroethylation of various classes of compounds. Frontiers Media S.A. 2019-03-04 /pmc/articles/PMC6409352/ /pubmed/30886846 http://dx.doi.org/10.3389/fchem.2019.00111 Text en Copyright © 2019 Carbonnel, Poisson, Jubault, Pannecoucke and Besset. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Chemistry
Carbonnel, Elodie
Poisson, Thomas
Jubault, Philippe
Pannecoucke, Xavier
Besset, Tatiana
Recent Advances for the Direct Introduction of the CF(2)Me Moiety
title Recent Advances for the Direct Introduction of the CF(2)Me Moiety
title_full Recent Advances for the Direct Introduction of the CF(2)Me Moiety
title_fullStr Recent Advances for the Direct Introduction of the CF(2)Me Moiety
title_full_unstemmed Recent Advances for the Direct Introduction of the CF(2)Me Moiety
title_short Recent Advances for the Direct Introduction of the CF(2)Me Moiety
title_sort recent advances for the direct introduction of the cf(2)me moiety
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409352/
https://www.ncbi.nlm.nih.gov/pubmed/30886846
http://dx.doi.org/10.3389/fchem.2019.00111
work_keys_str_mv AT carbonnelelodie recentadvancesforthedirectintroductionofthecf2memoiety
AT poissonthomas recentadvancesforthedirectintroductionofthecf2memoiety
AT jubaultphilippe recentadvancesforthedirectintroductionofthecf2memoiety
AT pannecouckexavier recentadvancesforthedirectintroductionofthecf2memoiety
AT bessettatiana recentadvancesforthedirectintroductionofthecf2memoiety