Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny

Current models propose that reductions in the number of lymphoid-biased hematopoietic stem cells (Ly-HSCs) underlie age-related declines in lymphopoiesis. We show that Ly-HSCs do not decline in number with age. Old Ly-HSCs exhibit changes in gene expression and a myeloid-biased genetic profile, but...

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Autores principales: Montecino-Rodriguez, Encarnacion, Kong, Ying, Casero, David, Rouault, Adrien, Dorshkind, Kenneth, Pioli, Peter D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409485/
https://www.ncbi.nlm.nih.gov/pubmed/30799276
http://dx.doi.org/10.1016/j.stemcr.2019.01.016
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author Montecino-Rodriguez, Encarnacion
Kong, Ying
Casero, David
Rouault, Adrien
Dorshkind, Kenneth
Pioli, Peter D.
author_facet Montecino-Rodriguez, Encarnacion
Kong, Ying
Casero, David
Rouault, Adrien
Dorshkind, Kenneth
Pioli, Peter D.
author_sort Montecino-Rodriguez, Encarnacion
collection PubMed
description Current models propose that reductions in the number of lymphoid-biased hematopoietic stem cells (Ly-HSCs) underlie age-related declines in lymphopoiesis. We show that Ly-HSCs do not decline in number with age. Old Ly-HSCs exhibit changes in gene expression and a myeloid-biased genetic profile, but we demonstrate that they retain normal lymphoid potential when removed from the old in vivo environment. Additional studies showing that interleukin-1 inhibits Ly-HSC lymphoid potential provide support for the hypothesis that increased production of inflammatory cytokines during aging underlies declines in lymphocyte production. These results indicate that current models proposing that lymphopoiesis declines with age due to loss of Ly-HSCs require revision and provide an additional perspective on why lymphocyte development in the elderly is attenuated.
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spelling pubmed-64094852019-03-21 Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny Montecino-Rodriguez, Encarnacion Kong, Ying Casero, David Rouault, Adrien Dorshkind, Kenneth Pioli, Peter D. Stem Cell Reports Article Current models propose that reductions in the number of lymphoid-biased hematopoietic stem cells (Ly-HSCs) underlie age-related declines in lymphopoiesis. We show that Ly-HSCs do not decline in number with age. Old Ly-HSCs exhibit changes in gene expression and a myeloid-biased genetic profile, but we demonstrate that they retain normal lymphoid potential when removed from the old in vivo environment. Additional studies showing that interleukin-1 inhibits Ly-HSC lymphoid potential provide support for the hypothesis that increased production of inflammatory cytokines during aging underlies declines in lymphocyte production. These results indicate that current models proposing that lymphopoiesis declines with age due to loss of Ly-HSCs require revision and provide an additional perspective on why lymphocyte development in the elderly is attenuated. Elsevier 2019-02-21 /pmc/articles/PMC6409485/ /pubmed/30799276 http://dx.doi.org/10.1016/j.stemcr.2019.01.016 Text en © 2019 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Montecino-Rodriguez, Encarnacion
Kong, Ying
Casero, David
Rouault, Adrien
Dorshkind, Kenneth
Pioli, Peter D.
Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny
title Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny
title_full Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny
title_fullStr Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny
title_full_unstemmed Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny
title_short Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny
title_sort lymphoid-biased hematopoietic stem cells are maintained with age and efficiently generate lymphoid progeny
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409485/
https://www.ncbi.nlm.nih.gov/pubmed/30799276
http://dx.doi.org/10.1016/j.stemcr.2019.01.016
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