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Lymphoid-Biased Hematopoietic Stem Cells Are Maintained with Age and Efficiently Generate Lymphoid Progeny

Current models propose that reductions in the number of lymphoid-biased hematopoietic stem cells (Ly-HSCs) underlie age-related declines in lymphopoiesis. We show that Ly-HSCs do not decline in number with age. Old Ly-HSCs exhibit changes in gene expression and a myeloid-biased genetic profile, but...

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Detalles Bibliográficos
Autores principales:	Montecino-Rodriguez, Encarnacion, Kong, Ying, Casero, David, Rouault, Adrien, Dorshkind, Kenneth, Pioli, Peter D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6409485/ https://www.ncbi.nlm.nih.gov/pubmed/30799276 http://dx.doi.org/10.1016/j.stemcr.2019.01.016

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